The Micro/Nanofluidics Laboratory, directed by
Brian Kirby, is a research group in the
Sibley School of Mechanical and Aerospace Engineering
at Cornell University devoted to research on understanding and
micro- and nanofluidic systems. Microfluidics and nanofluidics describe
fluid-mechanical regimes and devices defined by the length scale
of the flow channels, the techniques for making the devices,
and the dominant physics.
The evolution of electrokinetic potential observed at Zeonor-water
interfaces as a function of time. The decay is
fastest at low ambient pressures.
(see ref at the journal website
Growth and culture of neurons in microfluidic devices.
Fluorescence micrographs (middle right
and bottom), with corresponding device locations highlighted at
top, show stained (Calcein AM) cells indicating the
presence of axons within the channels. Growth of axons proceeds
from the somal chamber. (see ref here)
A circulating tumor cell captured by a GEDI device
and here) from peripheral blood of
a castrate-resistant prostate cancer patient shows differential response to chemotherapeutics that echoes clinical response.
Top: immunofluorescent stain of tubulin of a circulating tumor cell incubated with 100 nM docetaxel (Taxotere) shows diffuse
tubulin and no evidence of bundling. The absence of taxane response is indicative of a lack of drug-target engagement
and is consistent with this patient's failure to response to Taxotere therapy.
Bottom: immunofluorescent stain of tubulin of a cirulating tumor cell from the same patient incubated with 100 nM
paclitaxel (Taxol) shows pronounced tubulin bundling, indicative of drug-target engagement and consistent with this patient's
positive clinical response to Taxol.
Microfluidics/Nanofluidics Laboratory, 282 Grumman Hall, Cornell University, Ithaca, NY 14853 email webmaster with comments/corrections/questions