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Cornell Micro/Nanofluidics Laboratory
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The Micro/Nanofluidics Laboratory, directed by
Professor
Brian Kirby, is a research group in the
Sibley School of Mechanical and Aerospace Engineering
at Cornell University devoted to research on understanding and
application of
micro- and nanofluidic systems. Microfluidics and nanofluidics describe
fluid-mechanical regimes and devices defined by the length scale
of the flow channels, the techniques for making the devices,
and the dominant physics.
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Features
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Bill
and
Sarah
at our microbial cell culture facility, summer 2007, working on designing biomaterials
that allow study of
chondrocyte mechanotransduction.
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A circulating tumor cell captured by a GEDI device
(refs here
and here) from peripheral blood of
a castrate-resistant prostate cancer patient shows evidence of the TMPRSS2:ERG gene fusion. Top: DAPI stain of circulating
tumor cell nucleus. Bottom: ERG protein upregulation imaged with immunofluorescence is indicative of gene fusion.
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A schematic of the size-dependent trajectories and surface collisions used in
geometrically enhanced differential immunocapture, which we use to capture circulating tumor cells
from the peripheral blood of
castrate-resistant prostate cancer patients.
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Correlation between circulating tumor cell counts with Veridex CellSearch compared with our GEDI microdevices shows markedly
increased capture (ref here).
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