Kirby Lab Microfluidics / Nanofluidics : Biotoxin Detection

Cornell University, College of Engineering

Search Cornell

Home

Brian Kirby Bio

Staff and Facilities

Research Interests

Lab-on-a-Chip and BioMEMS devices

Biotoxin Detection

Bioenergy

Microfluidics

Nanofluidics

Cellular Analysis

Laser Microfabrication

Microparticle Processing

Interface Science

Projects

Research Positions Available

Courses

Micro/Nanofluidics Textbook

Publications

Presentation Schedule

Collaborators

Microfluidics Gordon Conference

TWiki site

Toxin and Pathogen Detection

Biological pathogens and toxins are of intense current interest due to the potential for bioterrorist activities along the lines of the ones occuring in the U.S. in the last few years. Developing automated, miniaturized biotoxin detection devices is one approach to establishing water surety, monitoring the safety of environmental waters, and maintaining counterbioterrorist efforts. These devices typically identify proteins or DNA that are characteristic of pathological organisms or are indicative of biotoxins themselves. Our chemical and particle analysis techniques are usually combined with biosensors-- for example, with collaborators such as Antje Baeumner.

Publications and Presentations pertinent to Toxin and Pathogen Detection

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems," AIChE 2006 San Francisco, CA, Nov 2006.

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan, Nov 2006.

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

Kirby BJ, Reichmuth DS, Renzi RF, Shepodd TJ, Wiedenman BJ
"Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements," Lab on a Chip 5:184-190 (2005). doi pdf text

Reichmuth DS, Chirica GS, Kirby BJ
"Analysis of peptides using an integrated microchip HPLC-MS/MS system," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

Song S, Singh AK, Kirby BJ
"Electrophoretic Concentration of Proteins at Laser-Patterned Porous Membranes," Analytical Chemistry 76:4589-4592 (2004). doi pdf text

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips," in Hilton Head MEMS Workshop 2004 (2004). pdf

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes", Analytical Chemistry 76:2367-2373 (2004). doi pdf text

Song S, Shepodd TJ, Singh AK, Kirby BJ
"Microchip-based dialysis of protein samples using photopatterned nanoporous membranes," in MicroTAS 2003, Kluwer Academic Publishers (2003). pdf

Fintschenko Y, Kirby BJ, Hasselbrink, Jr. EF, Singh AK, Shepodd TJ
"Monolithic Materials: Miniature and Microchip Technologies," in Monolithic Materials: Preparation, Properties, and Applications Elsevier, Amsterdam (2003). pdf

Kirby BJ, Singh AK
"In-situ Fabrication of Dialysis Membranes in Glass Microchannels Using Laser-induced Phase-separation Polymerization," in MicroTAS 2002, Kluwer Academic Publishers, pp. 742-744 (2002). pdf


	SEM of Mycobacterium tuberculosis, the causative agent of TB (image credit: CDC). We are studying the use of dielectrophoretic techniques to screen Mycobacterium cells.