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Toxin and Pathogen Detection
Biological pathogens and toxins are of intense current interest due to the potential for bioterrorist activities along the lines of the ones occuring in the U.S. in the last few years. Developing automated, miniaturized biotoxin detection devices is one approach to establishing water surety, monitoring the safety of environmental waters, and maintaining counterbioterrorist efforts. These devices typically identify proteins or DNA that are characteristic of pathological organisms or are indicative of biotoxins themselves. Our chemical and particle analysis techniques are usually combined with biosensors-- for example, with collaborators such as Antje Baeumner.

Archival Publications

PDF version of Gleghorn, Smith, Kirby
Transport and collision dynamics in periodic asymmetric obstacle arrays:
rational design of micro
fluidic rare cell immunocapture devices

Gleghorn JP, Smith JP, Kirby BJ
"Transport and collision dynamics in periodic asymmetric obstacle arrays: rational design of micro fluidic rare cell immunocapture devices", Physical Review E, 88, 032136 (2013). doi pdf

Hawkins, Huang, Arasanipalai, Kirby: Automated dielectrophoretic chracterization of Mycobacterium smegmatis

Hawkins BG, Huang C, Arasanipalai S, Kirby BJ
"Automated dielectrophoretic chracterization of Mycobacterium smegmatis," Analytical Chemistry, 83 (9), pp 3507–3515, 2011. doi pdf

PDF version of Hawkins, Kirby: Electrothermal flow effects in insulating 
(electrodeless) dielectrophoresis systems

Hawkins BG, Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems," Electrophoresis, 31:3622-3633, 2010. doi pdf

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

PDF version of Song, Singh, Kirby: Electrophoretic concentration of proteins at laser-patterned porous membranes

Song S, Singh AK, Kirby BJ
"Electrophoretic Concentration of Proteins at Laser-Patterned Porous Membranes," Analytical Chemistry 76:4589-4592 (2004). doi pdf text

PDF version of Song, Singh, Shepodd, Kirby: Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes", Analytical Chemistry 76:2367-2373 (2004). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Reichmuth, Renzi, Shepodd, Wiedenman: Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements

Kirby BJ, Reichmuth DS, Renzi RF, Shepodd TJ, Wiedenman BJ
"Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements," Lab on a Chip 5:184-190 (2005). doi pdf text

PDF versino of Fintschenko, Kirby, Hasselbrink, Singh, Shepodd: Monolithic materials: miniature and microchip technologies

Fintschenko Y, Kirby BJ, Hasselbrink, Jr. EF, Singh AK, Shepodd TJ
"Monolithic Materials: Miniature and Microchip Technologies," in Monolithic Materials: Preparation, Properties, and Applications Elsevier, Amsterdam (2003). pdf

Presentations and Other Publications
7 Nov 2012

Kirby BJ
"Electrokinetic and immunospecific characterization of cells for human health and energy applications", SUNY-Buffalo Chemical and Biomolecular Engineering Seminar Series, Buffalo, NY.

10-13 May 2012

Kirby BJ
"Geometric patterning: controlling small-scale flows with repeated microstructures", German--American Frontiers of Science Symposium, Potsdam, Germany. | video

7-12 Nov 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", AIChE 2010, Salt Lake City, UT.

3-7 Oct 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", MicroTAS 2010, Groningen, The Netherlands.

27 Jun-3 Jul 2009

Hawkins BG, Kirby BJ
Gordon Research Conference on Microfluidics, Lucca, Italy.

12-16 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic range particle separation via insulating dielectrophoresis", 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), San Diego, CA.

2-4 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic Range Dielelectrophoresis Devices for Cell Screening," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

9-13 July 2008 Hawkins BG, Gleghorn JP, Kondapalli S, Kirby BJ
"Sorting, capture, and concentration of cells in microdevices: geometric design", Joint meeting of the International Society of Biorheology (ISB) and the International Society for Clinical Hemorheology (ISCH), University Park, PA.
1 Oct 2007 Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype," Nanobiotechnology Symposium, Cornell University, Ithaca, NY.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," ASME Congress 2006 Chicago, IL.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan.

20 Sep 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," CNF annual meeting, Ithaca, NY

Nov 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems," AIChE 2006 San Francisco, CA.

Dec 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow dielectrophoretic particle separation in polymeric microchannels," 3rd New York Complex Matter Workshop Syracuse, NY.

Jun 2005

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields," 2nd New York Complex Matter Workshop Ithaca, NY.

Oct 2004
PDF version of Reichmuth, Chirica, Kirby: Analysis of peptides using an integrated microchip HPLC-MS/MS system

Reichmuth DS, Chirica GS, Kirby BJ
"Analysis of peptides using an integrated microchip HPLC-MS/MS system," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

May 2004
PDF version of Song, Singh, Shepodd, Kirby: Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips," in Hilton Head MEMS Workshop 2004 (2004). pdf

Oct 2003
PDF version of Song, Shepodd, Singh, Kirby: Microchip-based dialysis of protein samples using photopatterned nanoporous membranes

Song S, Shepodd TJ, Singh AK, Kirby BJ
"Microchip-based dialysis of protein samples using photopatterned nanoporous membranes," in MicroTAS 2003, Kluwer Academic Publishers (2003). pdf

Oct 2002
PDF version of Kirby, Singh: In-situ fabrication of dialysis membranes in glass microchannels using laser-induced phase-separation polymerization

Kirby BJ, Singh AK
"In-situ Fabrication of Dialysis Membranes in Glass Microchannels Using Laser-induced Phase-separation Polymerization," in MicroTAS 2002, Kluwer Academic Publishers, pp. 742-744 (2002). pdf

The MicroChemLab miniaturized system for chemical analysis of biotoxins (size approx 6"x4"x4"). This handheld, battery-operated system includes a microfabricated glass analysis chip, high voltage power supplies, laser-induced fluorescence detector, syringe sample injection, and both on-board memory and computer interface (courtesy Sandia National Labs).