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Cellular Analysis
Lab-on-a-Chip devices provide an exciting opportunity to perform unique cellular analyses, due to the potential for:
  • processing of extraordinarily small volumes (comparable to cellular contents)
  • rapid automated analysis
  • analysis of single cells
Our interests related to cellular analysis focus mainly on dielectrophoretic manipulation of cells and microfluidic capture of circulating tumor cells.

Archival Publications

HTML version of Kirby: Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices," Cambridge University Press, 2010.
click here for html version| Cambridge University Press

HTML page for Wilkes: Fluid Mechanics for Chemical Engineers with Microfluidics and CFD

Wilkes JO , with Birmingham SG, Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD," Prentice-Hall, 2005.
click here to go to text webpage

Saha T, Tsai S, Manning S, Thege FI, Voong C, Domchek S, Kirby BJ, Rhim AD
"Detection of circulating epithelial cells in BRCA mutation carriers without the diagnosis of cancer", submitted, 2014.

PDF version of Santana, Antonyak, Cerione, Kirby:
Microfluidic isolation of cancer-cell-derived microvesicles from heterogeneous extracellular shed vesicle populations

Santana SM, Antonyak MA, Cerione RA, Kirby BJ,
"Microfluidic isolation of cancer-cell-derived microvesicles from heterogeneous extracellular shed vesicle populations ", Biomedical Microdevices, 16:869–877, 2014. doi pdf

PDF version of Huang, Smith, Saha, Rhim, and Kirby:
Characterization of microfluidic shear-dependent EpCAM immunocapture and enrichment of pancreatic cancer cells from blood cells with dielectrophoresis

Huang C, Smith JP, Saha TM Rhim AD Kirby BJ
"Characterization of microfluidic shear-dependent EpCAM immunocapture and enrichment of pancreatic cancer cells from blood cells with dielectrophoresis", Biomicrofluidics, accepted, 2014. doi pdf

PDF version of Santana, Antonyak, Cerione, Kirby:
Cancerous Epithelial Cell Lines Shed Extracellular Vesicles With a Bimodal Size Distribution that is Sensitive to Glutamine Inhibition

Santana SM, Antonyak MA, Cerione RA, Kirby BJ,
"Cancerous Epithelial Cell Lines Shed Extracellular Vesicles With a Bimodal Size Distribution that is Sensitive to Glutamine Inhibition ", Physical Biology, 11:065001, 2014. doi pdf

PDF version of Rhim, Thege, Santana, Lannin, Kochman, Ginsberg, Lieb, Chandrasekhar, Drebin, Ahmad, Yang, Kirby, Stanger:
Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions

Rhim AD, Thege FI, Santana SM, Lannin TB, Kochman ML, Ginsberg GG, Lieb JG, Chandrasekhar V, Drebin JA, Ahmad N, Yang Y-X, Kirby BJ, Stanger BZ
"Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions", Gastroenterology 146:647:651, 2014. doi pdf

PDF version of Pratt, Stepansky, Hicks, Kirby:
Copy Number Analysis of Prostate Cancer Cells using GEDI Microdevices

Pratt ED, Stepansky A, Hicks J, Kirby BJ,
"Copy Number Analysis of Prostate Cancer Cells using GEDI Microdevices ", Analytical Chemistry, 86:11013-11017, 2014. doi pdf

PDF version of Galletti, Portella, Tagawa, Kirby, Giannakakou, Nanus:
Circulating tumor cells in prostate cancer diagnosis and monitoring: An appraisal of clinical potential

Galletti G, Portella L, Tagawa ST, Kirby BJ, Giannakakou PA, Nanus DM,
"Circulating tumor cells in prostate cancer diagnosis and monitoring: An appraisal of clinical potential ", Molecular Diagnostics and Therapy 2014. doi pdf

PDF version of Thege, Lannin, Saha, Tsai, Kochman, Hollingsworth, Rhim, Kirby:
Microfluidic immunocapture of circulating pancreatic cells with
parallel EpCAM and MUC1 capture modes

Thege FI, Lannin TB, Saha T, Tsai S, Kochman ML, Hollingsworth MA, Rhim AD, Kirby BJ,
"Microfluidic immunocapture of circulating pancreatic cells with parallel EpCAM and MUC1 capture modes", Lab Chip, 14:1775, 2014. doi pdf

PDF version of Galletti, Vahdat, Shah, Santana, Altavilla, Kirby, Giannakakou:
Isolation of breast cancer and gastric cancer circulating tumor cells by use of an anti HER2-based microfluidic device

Galletti G, Vahdat LT, Shah MA, Santana SM, Altavilla G, Kirby BJ, Giannakakou PA,
"Isolation of breast cancer and gastric cancer circulating tumor cells by use of an anti HER2-based microfluidic device ", Lab on a Chip, 14:147-156, 2014. doi pdf

PDF version of Huang, Santana, Liu, Bander, Hawkins, Kirby:
Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture

Huang C, Santana SM, Liu H, Bander NH, Hawkins BG, Kirby BJ
"Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture", Electrophoresis, 34:2970–2979, 2013. doi pdf

PDF version of Huang, Santana, Liu, Bander, Hawkins, Kirby:
Enrichment of prostate cancer cells from blood cells with a hybrid dielectrophoresis and immunocapture microfluidic system

Huang C, Liu H, Bander NH, Kirby BJ
"Enrichment of prostate cancer cells from blood cells with a hybrid dielectrophoresis and immunocapture microfluidic system", Biomedical Microdevices, 15(6):941-948, 2013. doi pdf

PDF version of Bono, Ahner, Kirby:
Detection of algal lipid accumulation due to nitrogen limitation via dielectric spectroscopy of Chlamydomonas reinhardtii suspensions in a coaxial transmission line sample cell

Bono MS, Ahner BA, Kirby BJ,
"Detection of algal lipid accumulation due to nitrogen limitation via dielectric spectroscopy of Chlamydomonas reinhardtii suspensions in a coaxial transmission line sample cell", Bioresource Technology, Volume 143, pp.623–631, 2013. doi pdf(with errata)

PDF version of Gleghorn, Smith, Kirby
Transport and collision dynamics in periodic asymmetric obstacle arrays:
rational design of micro
fluidic rare cell immunocapture devices

Gleghorn JP, Smith JP, Kirby BJ
"Transport and collision dynamics in periodic asymmetric obstacle arrays: rational design of micro fluidic rare cell immunocapture devices", Physical Review E, 88, 032136 (2013). doi pdf

PDF version of Zhu, Smith, Yarmush, Nahmias, Kirby, Murthy:
Microfluidic Enrichment of Mouse Epidermal Stem Cells and Validation of Stem Cell Proliferation In Vitro

Zhu B, Smith JP, Yarmush M, Nahmias Y, Kirby BJ, Murthy S,
"Microfluidic Enrichment of Mouse Epidermal Stem Cells and Validation of Stem Cell Proliferation In Vitro, Tissue Engineering C, 19(10):765-773, 2013. doi pdf

PDF version of Barbati, Fang, Banker, Kirby:
Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic
device for cell seeding, coherent growth, and solute delivery

Barbati AC, Fang C, Banker GA, Kirby BJ,
"Culture of primary rat hippocampal neurons: design, analysis, and optimization of a microfluidic device for cell seeding, coherent growth, and solute delivery", Biomedical Microdevices, Volume 15, Issue 1, pp 97-108, 2013. doi pdf

PDF version of Kirby, Jodari, Loftus, Gakhar, Pratt, Chanel-Vos, Gleghorn, Santana, Liu, Smith, Navarro, Tagawa, Bander, Nanus, Giannakakou, Kirby:
Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device

Kirby BJ, Jodari M, Loftus M, Gakhar G, Pratt ED, Chanel-Vos C, Gleghorn JP, Santana SM, Liu H, Smith JP, Navarro VN, Tagawa ST, Bander NH, Nanus DM, Giannakakou PA,
"Functional Characterization of Circulating Tumor Cells with a Prostate-Cancer-Specific Microfluidic Device ", PLoS ONE, 7(4): e35976, 2012. doi pdf

PDF version of AUTHORS: TITLE

Rouillard AD, Berglund CM, Lee JY, Polacheck WJ, Tsui YT, Bonassar LJ, Kirby BJ
"Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability," Tissue Engineering C, Vol 17(2), 2011. doi pdf

PDF version of Chandler, Berglund, Lee, Polacheck, Gleghorn, Fischbach: Stiffness of Photocrosslinked Alginate Gels Regulates
Adipose Progenitor Cell Behavior

Chandler EM, Berglund CM, Lee JS, Polacheck WJ, Gleghorn JP, Kirby BJ, Fischbach C
"Stiffness of Photocrosslinked Alginate Gels Regulates Adipose Progenitor Cell Behavior, Biotechnology and Bioengineering 108:7;1683-1692, 2011. doi pdf

Hawkins, Huang, Arasanipalai, Kirby: Automated dielectrophoretic chracterization of Mycobacterium smegmatis

Hawkins BG, Huang C, Arasanipalai S, Kirby BJ
"Automated dielectrophoretic chracterization of Mycobacterium smegmatis," Analytical Chemistry, 83 (9), pp 3507–3515, 2011. doi pdf

PDF version of AUTHORS: TITLE

Pratt ED, Huang C, Hawkins BG, Gleghorn JP, Kirby BJ
"Rare cell capture in microfluidic devices, Chemical Engineering Science, Vol 66(7)1508-1522, 2011. doi PubMedCentral pdf

PDF version of Rouillard, Tsui, Polacheck, Lee, Bonassar, Kirby: 
Control of the Electromechanical Properties of
Alginate Hydrogels via Ionic and Covalent
Cross-Linking and Microparticle Doping

Rouillard AD, Tsui YT, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Control of the Electromechanical Properties of Alginate Hydrogels via Ionic and Covalent Crosslinking and Microparticle Doping," Biomacromolecules, 11 (8), pp 2184–2189, 2010. doi pdf

PDF version of Hawkins, Kirby: Electrothermal flow effects in insulating 
(electrodeless) dielectrophoresis systems

Hawkins BG, Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems," Electrophoresis, 31:3622-3633, 2010. doi pdf

PDF version of Gleghorn, Pratt, Denning, Liu, Bander, Tagawa, Nanus, Giannakakou, Kirby:
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody

Gleghorn JP, Pratt ED, Denning D, Liu H, Bander NH, Tagawa S, Nanus DM, Giannakakou PA, Kirby BJ
"Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture and a prostate-specific antibody", Lab on a Chip, 10:27-29, 2010. doi PubMedCentral pdf

PDF version of AUTHORS: TITLE

Hawkins BG, Gleghorn JP, Kirby BJ
"Dielectrophoresis for cell and particle manipulations," in Methods in Bioengineering: Biomicrofabrication and Biomicrofluidics, Ed. J.D. Zahn, Artech Press, 2009. pdf

PDF version of Brian Kirby Nanofluidics review

Kirby BJ
"Nanofluidics" (book review), Materials Today, 12(5) 51, 2009. doi pdf

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

Presentations and Other Publications
16-18 Feb 2015

Kirby BJ
5th Annual Circulating Tumor Cells and Cell-Free DNA conference, Molecular Medicine Tri-Conference, San Francisco, CA.

16-21 Nov 2014

Kirby BJ
AES Electrophoresis Society 2014 Meeting, AIChE 2014 Annual Meeting, Atlanta, GA.

26-30 October 2014

Thege FI , Kirby BJ
Parallel capture of pancreatic cancer cells, uTAS 2014, San Antonio, TX.

22-25 Oct 2014

Godla ME , Kirby BJ
Using Rare Cell Capture to Understand Metastasis, BMES 2014, San Antonio, TX.

3-8 August 2014

Pratt ED , Stepansky A , Hicks J , Kirby BJ
Single-nucleus sequencing of prostate cancer cells captured with GEDI microdevices, Gordon Research Conference on Rare Cells in Circulation, South Hadley, MA.

3-8 August 2014

Hartman J , Huang C , Kirby BJ
Hybrid immunocapture of ovarian cancer cells, Gordon Research Conference on Rare Cells in Circulation, South Hadley, MA.

3-8 August 2014

Thege FI , Kirby BJ
Parallel capture of pancreatic cancer cells, Gordon Research Conference on Rare Cells in Circulation, South Hadley, MA.

5-11 July 2014

Pratt ED , Stepansky A , Hicks J , Kirby BJ
Single-nucleus sequency of prostate cancer cells captured with GEDI microdevices, Gordon Research Conference on Genomic Instability, Hong Kong, CN.

21-22 June 2014

Lannin TB
Electrorotation of Cancer Cells to Optimize Performance of Dielectrophoresis Capture Devices, Gordon Research Conference on Bioanalytical Sensors, Newport, RI.

15-21 June 2014

Godla ME
Using Rare Cell Capture to Understand Metastasis, 13th International Summer School on Biocomplexity, Biodesign, and Bioinnovation, Istanbul, Turkey.

16-20 Mar 2014

Bono MS , Ahner BA , Kirby BJ
Multiplex measurement of algal lipid content via dielectric spectroscopy, flow cytometry, and 1H NMR, Division of Analytical Chemistry oral session on Analytical Chemistry in Energy, 2014 ACS National Meeting, Dallas, Texas.

7 Mar 2014

Lannin TB
Electrorotation of Cancer Cells to Optimize Performance of Dielectrophoresis Capture Devices, Sibley Graduate Research Symposium, Ithaca, NY.

13 Mar 2014

Kirby BJ
Cornell Materials Science Colloquium, Ithaca, NY.

18-22 Jan 2014

Smith JP , Gleghorn JP , Godla ME , Huang C , Lannin TB , Pratt ED , Santana SM , Thege FI , Kirby BJ
Circulating tumor cell (CTC) cancer biomarkers using geometrically enhanced differential immunocapture (GEDI) microdevices, Society for Lab Automation and Screening 2014, San Diego, CA

17 Jan 2014

Kirby BJ
Geometrically Enhanced Differential Immunocapture: Using obstacle arrays in microfluidic devices to enhance efficient and pure rare cell capture from fluid suspensions, Edwards Lecture, Oregon State University, Corvallis, OR.

7-11 Jan 2014

Santana SM , Fischbach-Teschl C , Kirby BJ ,
On-chip Tumor Microenvironment for Circulating Tumor Cell Isolation and Culture, Biomedical Engineering Society - Cellular and Molecular Bioengineering Meeting 2014, La Jolla, CA.

24-26 Nov 2013

Barbati AC , Kirby BJ
Streaming potential and conductivity measurements reveal electrokinetic properties of porous and charged layers, 66th Annual Meeting of the APS Division of Fluid Dynamics, November 24–26, 2013; Pittsburgh, Pennsylvania.

27-31 Oct 2013

Thege FI , Santana SM , Lannin TB , Tsai S , Saha TN , Godla ME , Pratt ED , Rhim AD , Kirby BJ
Parallelized Microfluidic Immunocapture of Circulating Pancreatic Cells for Genetic Analysis and Early Detection of Pancreatic Carcinogenesis MicroTAS 2013, Freiburg, Germany.

27-31 Oct 2013

Santana SM , Antonyak MA , Fischbach-Teschl C , Cerione RA , Kirby BJ
Novel Microfluidic Platforms for the Interrogation of Patient-Derived CTCs and Tumor-Derived Microvesicles MicroTAS 2013, Freiburg, Germany.

27-31 Oct 2013

Huang C , Smith JP , Liu H , Bander NH , Kirby BJ
Enrichment of prostate cancer cells from blood cells with a hybrid dielectrophoresis and immunocapture microfluidic system MicroTAS 2013, Freiburg, Germany.

25-28 Sep 2013

Huang C , Smith JP , Liu H , Bander NH , Kirby BJ
A Hybrid Dielectrophoresis and Immunocapture System for Enhanced Capture of Circulating Tumor Cells BMES 2013, Seattle, WA.

25-28 Sep 2013

Lannin TB , Sung MS , Thege FI , Syed YA , Galletti GI , Rhim AD , Giannakakou PA , Kirby BJ
Machine Learning Outperforms Manual Counting for Classifying Circulating Tumor Cells from Cancer Patients BMES 2013, Seattle, WA.

25-28 Sep 2013

Huang C , Santana SM , Antonyak MA , Fischbach-Teschl C , Cerione RA , Kirby BJ
Novel Micro?uidic Platforms for the Interrogation of Patient-Derived CTCs and Tumor-Derived Microvesicles BMES 2013, Seattle, WA.

25-28 Sep 2013

Thege FI , Santana SM , Rhim AD , Kirby BJ
Multiplexed Micro?uidic Immunocapture of Circulating Pancreas Cells for the Early Detection of Pancreatic Carcinogenesis BMES 2013, Seattle, WA.

19 Sep 2013

Huang C , Smith JP , Kirby BJ
A Hybrid Dielectrophoresis and Immunocapture Microfluidic System for Enhanced Rare Cell Capture Cornell NanoScale Science & Technology Facility Annual Meeting, Ithaca, NY.

28-31 Jul 2013

Kirby BJ
Electrokinetic response in systems with fluid-permeable and charged layers, Society of Engineering Science ASME-AMD Summer Meeing, 2013, Providence, RI.

9-14 Jun 2013

Thege FI , Santana SM , Rhim AD , Kirby BJ
Multiplexed Micro?uidic Immunocapture of Circulating Pancreas Cells for the Early Detection of Pancreatic Carcinogenesis Gordon Research Conference on the Physics and Chemistry of Microfluidics, 2013, Lucca, Italy.

9-14 Jun 2013

Lannin TB , Sung MS , Thege FI , Syed YA , Galletti GI , Rhim AD , Giannakakou PA , Kirby BJ
Machine Learning Outperforms Manual Counting for Classifying Circulating Tumor Cells from Cancer Patients Gordon Research Conference on the Physics and Chemistry of Microfluidics, 2013, Lucca, Italy.

9-14 Jun 2013

Kirby BJ , Gleghorn JP , Godla ME , Huang C , Lannin TB , Pratt ED , Santana SM , Smith JP , Syed YA , Thege FI
Capture and interrogation of circulating tumors cells by use of geometrically enhanced differential immunocapture (GEDI) microfluidic devices Gordon Research Conference on the Physics and Chemistry of Microfluidics, 2013, Lucca, Italy.

6-7 Jun 2013

Kirby BJ
Select Biosciences 2013 Nano and Microfluidics conference, CCH Congress Centre, Hamburg Germany.

31 May-4 Jun 2013

Antonarakis ES , Giannakakou PA , Kirby BJ , Nicasio LV , Eisenberger MA , Nanus DM , Tagawa ST
TAXYNERGY (NCT01718353): A randomized phase II trial examining an early switch from first-line docetaxel to cabazitaxel, or cabazitaxel to docetaxel, in men with metastatic castration-resistant prostate cancer (mCRPC) ASCO 2013, Chicago, IL.

6-10 Apr 2013

Galletti GI , Kirby BJ , Vahdat LT , Giannakakou PA
Development of a HER2-based GEDI microfluidic device for the molecular characterization of CTCs from metastatic breast cancer patients AACR 2013, Washington, DC.

6-10 Apr 2013

Sung MS , Gyrezi A , Lee GY , Matov A , Galletti GI , Loftus M , Syed YA , Lannin TB , Hristov A , Mason C , Tagawa S , Kirby BJ , Nanus DM , Giannakakou PA
Using CTCs to interrogate mechanisms of taxane resistance in the prospective TAXYNERGY clinical trial in prostate cancer AACR 2013, Washington, DC.

28 Mar 2013

Bono MS , Ahner BA , Kirby BJ
Quantitative in situ measurement of algal lipid content via dielectric spectroscopy, Division of Analytical Chemistry oral session on "Characterization of Algal Lipids" at the 245th ACS National Meeting, New Orleans, Louisiania.

17-21 Mar 2013

Kirby BJ
"Functional Characterization of Circulating Tumor Cells Captured With GEDI Microdevices", Pittcon 2013, Philadelphia, PA.

10-15 Feb 2013

Santana SM , Fischbach-Teschl C , Kirby BJ ,
Capture and Interrogation of Circulating Tumor Cells in Tissue-Engineered Geometrically Enhanced Differential Immunocapture Microfluidic Devices Gordon Research Conference on Fibronectin, Integrins, & Related Molecules, 2013, Ventura, CA.

12-16 Nov 2012

Pratt ED , Gleghorn JP , Loftus M , Jodari M , Santana SM , Smith JP , Stepansky A , Giannakakou PA , Hicks J , Nanus DM , Rhim AD , Stanger BZ , Kirby BJ
Functional and genetic analysis of CTCs captured with GEDI microdevices, World CTC Summit Boston 2012, Boston, MA.

7 Nov 2012

Kirby BJ
"Electrokinetic and immunospecific characterization of cells for human health and energy applications", SUNY-Buffalo Chemical and Biomolecular Engineering Seminar Series, Buffalo, NY.

24-27 Oct 2012

Pratt ED , Blattner M , Stepansky A , Liu H , Bander NH , Hicks J , Rubin MA , Kirby BJ
"Microfluidic Nuclei Extraction from Circulating Tumor Cells for Genetic Analyses", BMES 2012, Atlanta, Georgia.

24-27 Oct 2012

Huang C , Kirby BJ
"DEP-enhanced immunocapture of Circulating Tumor Cells in GEDI Microdevices", BMES 2012, Atlanta, Georgia.

24-27 Oct 2012

Santana SM , Fischbach C , Kirby BJ
"Immunocapture of Circulating Tumor Cells in Tissue-Engineered GEDI Microdevices", BMES 2012, Atlanta, Georgia.

24-27 Oct 2012

Kirby BJ
"Dielectric Spectrometry of Mycobacterium and GEDI Devices for Circulating Tumor Cells: Cell Capture, Characterization, and Manipulation in Geometrically Patterned Microstructures", BMES 2012, Atlanta, Georgia.

30 Sep-5 Oct 2012

Kirby BJ
"Dielectric and dielectrophoretic measurements and manipulations of cells for human health and energy applications", SciX 2012, Kansas City, MO.

19-21 Sep 2012

Kirby BJ
CHI ADAPT 2012, Washington, DC.

17 Aug 2012

Huang C , Santana SM , Hawkins BG , Liu H , Bander NH , Kirby BJ
"Dielectrophoresis-Enhanced Immunocapture of Prostate Cancer Cells", cornell BMES Retreat, Ithaca, NY.

10-13 May 2012

Kirby BJ
"Geometric patterning: controlling small-scale flows with repeated microstructures", German--American Frontiers of Science Symposium, Potsdam, Germany. | video

31 Mar-4 Apr 2012

Galletti G, , Kirby BJ , Vahdat L , Giannakakou PA
Development of a novel microfluidic device for the capture and molecular characterization of circulating tumor cells from metastatic breast cancer patients 103nd annual AACR meeting 2012, Chicago, IL.

31 Mar-4 Apr 2012

Sung M , Loftus M , Jodari-Karimi M , Pratt ED , Gakhar G , Rubin M , Bander N , Novaro , Tagawa ST , Kirby BJ , Nanus DM , Giannakakou PA
Molecular and functional analysis of circulating prostate tumor cells with anti-PSMA immunocapture 103nd annual AACR meeting 2012, Chicago, IL.

28 Mar 2012

Bono MS , Rhoads K , Ahner BA , Kirby BJ
Dielectric measurement of algal lipid content, Division of Analytical Chemistry oral session on "Challenges in Algal Biofuels: Biochemistry, Lipid Extraction and Analysis" at the 243rd ACS National Meeting, San Diego, California.

2-3 Feb 2012

Kirby BJ
Select Biosciences Meeting on Circulating Tumor Cells, San Diego, CA.

12-15 Oct 2011

Kirby BJ, Pratt ED, Santana SM, Smith JP, Gleghorn JP, Liu H, Bander NH, Jodari M, Loftus M, Nanus DM, Giannakakou PA,
"Functional Characterization of drug-target engagement on high-purity CTCs correlate with patient progression", BMES 2011, Hartford, CT.

6-9 Oct 2011

Huang C , Hawkins BG , Arasanipalai S , Kirby BJ
Dielectrophoretic characterization of Mycobacteria and Prostate Cancer Cells, BMES 2011 Annual Meeting, Hartford, CT.

2-6 Oct 2011

Kirby BJ, Pratt ED, Santana SM, Smith JP, Gleghorn JP, Jodari M, Gakhar G, Loftus M, Liu H, Bander NH, Nanus DM, Giannakakou PA,
"Functional Characterization of drug-target engagement on high-purity CTCs correlate with patient progression", MicroTAS 2011, Seattle, WA.

2-6 Oct 2011

Pratt ED, Santana SM, Gleghorn JP, Liu H, Bander NH, Nanus DM, Giannakakou PA, Kirby BJ
"Circulating tumor cell release by use of novel immunocapture chemistry in GEDI microdevices", MicroTAS 2011, Hartford, CT.

1 Oct 2011

Kirby BJ
Microfluidic capture of circulating tumor cells for assay of chemotherapeutic efficacy: system design and translation to the clinical setting Cornell Translational Cancer Research Symposium, Ithaca, NY

15 sept 2011

Arasanipalai S , Hawkins BG , Huang C , Kirby BJ
Dielectrophoretic separation of Mycobacteria to aid in Tuberculosis research, CNF 2011 Annual Meeting, Ithaca, NY.

10 Jun 2011

Arasanipalai S , Huang C , Hawkins BG , Kirby BJ
Dielectrophoretic separation of Mycobacteria to aid in tuberculosis research, 11th New York Complex Matter Workshop, Syracuse, NY.

10 Jun 2011

Bono MS , Rhoads K , Ahner BA , Kirby BJ
Dielectric measurement of algal lipid content for biodiesel production, 11th New York Complex Matter Workshop, Syracuse, NY.

19-20 Apr 2011

Kirby BJ
NSF National Nanotechnology Infrastructure Network Computation Symposium, Ann Arbor, MI.

2-6 Apr 2011

Loftus M , Jodari-Karimi M , Pratt ED , Gakhar G , Rubin M , Bander N , Novaro , Tagawa ST , Kirby BJ , Nanus DM , Giannakakou PA
Molecular and functional analysis of circulating tumor cells in castrate resistant prostate cancer using a geometrically enhanced microfluidic device based on PSMA immunocapture, 102nd annual AACR meeting 2011, Orlando, FL.

30 Mar 2011

Bono MS , Kirby BJ
Microfluidic dielectric spectroscopy of particle and cell solutions, Division of Analytical Chemistry poster session at the 241st ACS National Meeting, Anaheim, California.

23-25 Feb 2011

Kirby BJ
CHI Meeting on Circulating Tumor Cells (CTCs) for Cancer Detection, Diagnosis, Prognosis and Treatment, San Francisco, CA.

17-19 Feb 2011

Jodari M , Loftus M , Gleghorn JP , Gakhar G , Pratt ED , Tagawa ST , Bander NH , Giannakakou PA , Kirby BJ , Nanus DM
"Capture and analysis of prostate cancer circulating tumor cells (CTCS) by use of geometrically enhanced differential immunocapture (GEDI)", 2011 Genitourinary Cancers Symposium, Orlando, FL.

7-11 Feb 2011

Kirby BJ
Lorentz workshop on circulating tumor cells, Leiden, The Netherlands.

12-18 Nov 2010

Smith JP , Gleghorn JP , Kirby BJ
"Particle collision dynamics of microparticles in microfluidic obstacle arrays", ASME 2010 International Mechanical Engineering Congress and Exposition, Vancouver, BC.

7-12 Nov 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", AIChE 2010, Salt Lake City, UT.

7-12 Nov 2010

Gleghorn JP , Smith JP , Kirby BJ
"Particle collision dynamics of microparticles in microfluidic obstacle arrays", AIChE 2010, Salt Lake City, UT.

6-9 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", BMES 2010, Austin, TX.

6-9 Oct 2010

Huang C , Hawkins BG , Arisanipalai S , Kirby BJ
"Automated dielectrophoretic characterization for microfluidic cell separation devices", BMES 2010, Austin, TX.

3-7 Oct 2010

Barbati AC , Fang C , Banker GA , Kirby BJ
"Experimentation and modeling of a microfluidic device demonstrating geometric coercion for the directed growth and observation of rat hippocampal neurons", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Huang C , Hawkins BG , Arisanipalai S , Kirby BJ
"Automated dielectrophoretic characterization for microfluidic cell separation devices", MicroTAS 2010, Groningen, The Netherlands.

22 Sep 2010

Kirby BJ
"Microfluidic capture and analysis of CTCs from peripheral blood of prostate cancer patients", Georgia Tech Chemical and Biomolecular Engineering Seminar, Atlanta, GA.

15 July 2010

Kirby BJ
"Microfluidic devices for capture and analysis of prostate cancer CTCs from peripheral blood samples", Memorial Sloan-Kettering Cancer Center, New York, NY.

20-25 June 2010

Pratt ED , Gleghorn JP , Santana SM , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", Gordon Research Conference on Bioanalytical Sensors, Colby-Sawyer College, New London, NH.

20-25 June 2010

Kirby BJ
"Microfluidic devices for capture and analysis of prostate cancer CTCs from peripheral blood samples", Gordon Research Conference on Bioanalytical Sensors, Colby-Sawyer College, New London, NH.

18 June 2010

Smith JP, Gleghorn JP, Kirby BJ
"Particle Collision Dynamics in Geometrically Enhanced Differential Immunocapture (GEDI) Microdevices", 10th New York Complex Matter Workshop, Ithaca, NY.

18 June 2010

Santana SM, Gleghorn JP, Kirby BJ
"Immunocapture and Release of Viable Circulating Tumor Cells in Microdevices", 10th New York Complex Matter Workshop, Ithaca, NY.

18 June 2010

Huang C, Hawkins BG, Kirby BJ
"Automated Dielectrophoretic Characterization for Microfluidic Cell Separation", 10th New York Complex Matter Workshop, Ithaca, NY.

17-21 April 2010

Loftus MS , Gleghorn JP , Pratt ED , Bander NH , Nanus DM , Kirby BJ
Giannakakou P
"Analysis of circulating tumor cells from castrate resistant prostate cancer patients captured via a microfluidic device using an anti-PSMA antibody", American Association of Cancer Researchers 2010 Annual Meeting, Washington, DC.

6-9 Mar 2010

Rouillard AD, Berglund CM, Lee JY, Polacheck WJ, Tsui YT, Bonassar LJ, Kirby BJ
"Methods for photocrosslinking alginate hydrogel scaffolds with high cell viability," Orthopedic Research Society Meeting, New Orleans, LA, March 2010.

1-5 Nov 2009 Barbati AC , Fang C, Banker GA, Kirby BJ
"Microfluidic Device and Culture Platform for the Observation and Control of Axonal Growth and Axonal Organelle Transport of Rat Hippocampal Neurons", MicroTAS 2009, Jeju, Korea.
1-5 Nov 2009

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"On-chip electrophoretic concentration of liposomes for antibody-based viral biosensors", MicroTAS 2009, Jeju, Korea.

1-5 Nov 2009 Gleghorn JP, Pratt ED, Loftus MS, Levy BE, Bander NH, Nanus DM, Giannakakou PA, Kirby BJ
"High efficiency capture of circulating tumor cells from patient blood using geometrically-enhanced differential immunocapture", MicroTAS 2009, Jeju, Korea.
27 Jun-3 Jul 2009

Hawkins BG, Kirby BJ
Gordon Research Conference on Microfluidics, Lucca, Italy.

27 Jun-3 Jul 2009

Barbati AC, Kirby BJ
Gordon Research Conference on Microfluidics, Lucca, Italy.

5 Mar 2009

Berglund CM, Lee JY, Yang W, Lee JS, Chandler EM, Fischbach CF, Kirby BJ
"Synthesis and Characterization of Photocrosslinked Alginate Hydrogels", Bioengineering Expo, Ithaca, NY.

5 Mar 2009

Lee JY, Berglund CM, Yang W, Gleghorn JP, Bonassar LJ, Kirby BJ
"Biological Characterization of Chondrocytes Seeded in Photocrosslinked Alginate Tissue Scaffolds", Bioengineering Expo, Ithaca, NY.

30 Jan 2009

Kirby BJ
"Geometric micro- and mesopatterning for control of cell transport and microenvironemnt in microdevices and tissue-engineered scaffolds", Carnegie-Mellon Mechanical Engineering Seminar Series, Pittsburgh, PA.

27 Oct 2008

Kirby BJ
"Geometric patterning to control cell growth, capture, and transport", NBTC Annual Symposium, Ithaca, NY.

12-16 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic range particle separation via insulating dielectrophoresis", 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), San Diego, CA.

2-4 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic Range Dielelectrophoresis Devices for Cell Screening," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

9-13 July 2008 Hawkins BG, Gleghorn JP, Kondapalli S, Kirby BJ
"Sorting, capture, and concentration of cells in microdevices: geometric design", Joint meeting of the International Society of Biorheology (ISB) and the International Society for Clinical Hemorheology (ISCH), University Park, PA.
10 apr 2008

Kirby BJ
"Electrokinetic Tool of Cellular Screening in Plastic Microdevices: Interfacial Characterization and Engineering Design", Temple University Chemistry Department, Philadelphia, PA.

21 Mar 2008

Kirby BJ
"Cell processing in microdevices: sorting, capturing, and concentration techniques", University of Rochester Biomedical Engineering Department, Rochester, NY.

4 Mar 2008

Kirby BJ
"Micropatterning in injection-molded microdevices and engineered tissue scaffolds: the role of electrokinetic coupling", University of Illinois Mechancal Science and Engineering Department, Urbana, IL

4-9 Nov 2007

Hawkins BG, Smith AE, Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic screening of Mycobacterium smegmatis in coherently patterned, polymeric microchannels", AIChE 2007, Salt Lake City, UT, November 2007.

7-12 Oct 2007.

Hawkins BG, Tandon V, Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial characterization and engineering design", Meeting of the Electrochemical Society, Washington, DC.

7-11 Oct 2007

Hawkins BG, Smith AE, Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic screening of Mycobacterium smegmatis in coherently patterned, polymeric microchannels", MicroTAS 2007, Paris, France, October 2007.

7-11 Oct 2007

Rouillard AD, Tsui Y, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Micropatterned hydrogel tissue scaffolds with controlled electrokinetic properties for investigation of chondrocyte mechanotransduction", MicroTAS 2007, Paris, France, October 2007.

1 Oct 2007
PDF version of Chandler, Berglund, Lee, Polacheck, Gleghorn, Fischbach: Stiffness of Photocrosslinked Alginate Gels Regulates
Adipose Progenitor Cell Behavior

Chandler EM, Cossell CM, Polacheck WJ, Lee JY, Kirby BJ, Fischbach C
"Effect of Substrate Stiffness on Heterotypic Cellular Interactions in Breast Cancer, Nanobiotechnology Symposium, Cornell University, Ithaca, NY. doi pdf

1 Oct 2007 Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype," Nanobiotechnology Symposium, Cornell University, Ithaca, NY.
26-29 Sep 2007

Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype,"  BMES 2007, Los Angeles, CA.

26-29 Sep 2007

Rouillard AD, Tsui Y, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Control of the electromechanical proterties of alginate tissue scaffolds via ionic and covalent crosslinking and microparticle doping", BMES 2007, Los Angeles, CA

15-20 Jul 2007

Hawkins BG, Smith AE, Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH.

10 May 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", University of Toronto Analytical Chemistry Seminar Series, Toronto, Canada.

24 Apr 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", Lafayette Bioengineering and Biomedicine Symposium, Easton, PA.

26 Feb 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Biological and Environmental Engineering Seminar Series, Cornell University, Ithaca, NY.

25 Jan 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Textiles and Apparel Seminar Series, Cornell University, Ithaca, NY.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," ASME Congress 2006 Chicago, IL.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan.

6 Oct 2006

Kirby BJ
"Fabrication for design and control of micro/nanofluidic systems", University of Michigan Mechanical Engineering Seminar Series, Ann Arbor, MI.

20 Sep 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," CNF annual meeting, Ithaca, NY

Nov 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems," AIChE 2006 San Francisco, CA.

Oct 2006

Rouillard AD, Bonassar LJ, Kirby BJ
"Control of electrokinetic properties of hydrogels for studies of mechanotransduction in chondrocytes," BMES Annual Meeting Chicago, IL.

21 Jun 2006

Kirby BJ
"Electrokinetics in fluid systems: Control of fields with multiscale geometric patterning", 2nd New York Complex Matter Workshop, Ithaca, NY.

Jun 2006

Rouillard AD, Bonassar LJ, Kirby BJ
"Studying cell mechanotransduction in chondrocytes via manipulation of electrokinetics in alginate hydrogels," 2nd New York Complex Matter Workshop Ithaca, NY.

Dec 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow dielectrophoretic particle separation in polymeric microchannels," 3rd New York Complex Matter Workshop Syracuse, NY.

12 Jan 2006

Kirby BJ
"Miniaturized devices for combinatorial chemistry and nanofluidic study", Sandia National Laboratories, Livermore, CA.

9 Dec 2005

Kirby BJ
Kodak Research Laboratories, Rochester, NY.

10 Nov 2005

Kirby BJ
Mechanical Engineering and Applied Mechanics Department, University of Pennsylvania, Philadelphia, PA.

27 Oct 2005

Kirby BJ
Dept. of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark.

18 Oct 2005

Kirby BJ
Nanobiotechnology Center, Cornell University, Ithaca, NY.

27 Sep 2005

Kirby BJ
Cornell Fluid Dynamics Seminar, Ithaca, NY.

25 July 2005

Kirby BJ
Gordon Research Conference on the Physics and Chemistry of Microfluidics, Oxford, UK.

Jun 2005

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields," 2nd New York Complex Matter Workshop Ithaca, NY.

10 Feb 2005

Kirby BJ
APS March Annual Meeting, San Francisco, CA.

10 Feb 2005

Kirby BJ
Johns Hopkins Mechanical Engineering Seminar Series, Baltimore, MD.

Oct 2004
PDF version of Song, Mela, van den Berg, Kirby: Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus

Song S, Mela P, van den Berg A, Kirby BJ
"Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

Oct 2001
PDF version of Kirby, Wheeler, Shepodd, Fruetel, Hasselbrink, Zare: A laser-polymerized thin film silica surface modification for suppression of cell adhesion and electroosmotic flow in microchannels

Kirby BJ, Wheeler AR, Shepodd TJ, Fruetel JA, Hasselbrink, Jr. EF, Zare RN
"A Laser-Polymerized Thin Film Silica Surface Modification for Suppression of Cell Adhesion and Electroosmotic Flow in Microchannels," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Oct 2001
PDF version of Wheeler, Morishima, Kirby, Leach, Zare: CATH.a neuron cell analysis on a chip with micellar electrokinetic chromatography

Wheeler AR, Morishima K, Kirby BJ, Leach A, Zare RN
"CATH.a Neuron Cell Analysis on a Chip With Micellar Electrokinetic Chromatography," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Growth and culture of neurons in microfluidic devices. Fluorescence micrographs (middle right and bottom), with corresponding device locations highlighted at top, show stained (Calcein AM) cells indicating the presence of axons within the channels. Growth of axons proceeds from the somal chamber. (see ref here)
Correlation between circulating tumor cell counts with Veridex CellSearch compared with our GEDI microdevices shows markedly increased capture (ref here).
Immunostaining of a prostate cancer circulating tumor cell (see ref here)