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Cellular Analysis
Lab-on-a-Chip devices provide an exciting opportunity to perform unique cellular analyses, due to the potential for:
  • processing of extraordinarily small volumes (comparable to cellular contents)
  • rapid automated analysis
  • analysis of single-cells
Our interests related to cellular analysis focus mainly on laser-manipulation and lysing of cells combined with microchip dialysis of cytosolic contents.

Selected Publications and Presentations on Cellular Analysis

Rouillard AD, Tsui Y, Polacheck WJ, Lee JY, Bonassar LJ, Kirby BJ
"Micropatterned hydrogel tissue scaffolds with controlled electrokinetic properties for investigation of chondrocyte mechanotransduction", MicroTAS 2007, Paris, France, October 2007.

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan, Nov 2006.

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

PDF version of Wheeler, Morishima, Kirby, Leach, Zare: CATH.a neuron cell analysis on a chip with micellar electrokinetic chromatography

Wheeler AR, Morishima K, Kirby BJ, Leach A, Zare RN
"CATH.a Neuron Cell Analysis on a Chip With Micellar Electrokinetic Chromatography," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Dielectrophoretic manipulation of particles in ridged microstructures. Top view. Black-white color table denotes local electric field magnitude. Red and green visualize particle types. Field of view in this movie is ~2000 microns. Place mouse on image to animate.