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Laser-Microfabrication
Our interests in laser-microfabrication fall into two categories:
  • rapid-prototyping of microfluidic systems using laser-etching. Here, a focused laser beam is used to ablate the substrate material and the motion of the laser along the substrate defines the microdevice geometry.
  • laser-patterning of polymer microelements in glass microsystems. Here, a shaped laser beam is used to polymerize elements from a solution that has been injected into a microdevice. In these applications, hybrid glass-polymer microsystems are generated with functionality not possible in single-material systems.

Archival Publications
PDF version of Song, Singh, Kirby: Electrophoretic concentration of proteins at laser-patterned porous membranes

Song S, Singh AK, Kirby BJ
"Electrophoretic Concentration of Proteins at Laser-Patterned Porous Membranes," Analytical Chemistry 76:4589-4592 (2004). doi pdf text

PDF version of Song, Singh, Shepodd, Kirby: Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes", Analytical Chemistry 76:2367-2373 (2004). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: On-chip high-pressure picoliter injector for pressure-driven flow through porous media

Reichmuth DS, Shepodd TJ, Kirby BJ
"On-chip high-pressure picoliter injector for pressure-driven flow through porous media," Analytical Chemistry 76:5063-5068 (2004). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Reichmuth, Renzi, Shepodd, Wiedenman: Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements

Kirby BJ, Reichmuth DS, Renzi RF, Shepodd TJ, Wiedenman BJ
"Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements," Lab on a Chip 5:184-190 (2005). doi pdf text

PDF versino of Fintschenko, Kirby, Hasselbrink, Singh, Shepodd: Monolithic materials: miniature and microchip technologies

Fintschenko Y, Kirby BJ, Hasselbrink, Jr. EF, Singh AK, Shepodd TJ
"Monolithic Materials: Miniature and Microchip Technologies," in Monolithic Materials: Preparation, Properties, and Applications Elsevier, Amsterdam (2003). pdf

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

PDF version of Kirby, Shepodd, Hasselbrink: Voltage-addressable on/off microvalves for high-pressure microchip separations

Kirby BJ, Shepodd TJ, Hasselbrink, Jr. EF
"Voltage-Addressable On/Off Microvalves for High-Pressure Microchip Separations," Journal of Chromatography A 979:147-154 (2002). doi pdf

Presentations and Other Publications
1-5 Nov 2009

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"On-chip electrophoretic concentration of liposomes for antibody-based viral biosensors", MicroTAS 2009, Jeju, Korea.

Oct 2004
PDF version of Reichmuth, Chirica, Kirby: Analysis of peptides using an integrated microchip HPLC-MS/MS system

Reichmuth DS, Chirica GS, Kirby BJ
"Analysis of peptides using an integrated microchip HPLC-MS/MS system," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

Oct 2004
PDF version of Song, Mela, van den Berg, Kirby: Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus

Song S, Mela P, van den Berg A, Kirby BJ
"Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

May 2004
PDF version of Song, Singh, Shepodd, Kirby: Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips," in Hilton Head MEMS Workshop 2004 (2004). pdf

Oct 2003
PDF version of Reichmuth, Shepodd, Kirby: RP-HPLC microchip separations with subnanoliter on-chip pressure injections

Reichmuth DS, Shepodd TJ, Kirby BJ
"RP-HPLC microchip separations with subnanoliter on-chip pressure injections," in MicroTAS 2003, Kluwer Academic Publishers (2003). pdf

Oct 2003
PDF version of Song, Shepodd, Singh, Kirby: Microchip-based dialysis of protein samples using photopatterned nanoporous membranes

Song S, Shepodd TJ, Singh AK, Kirby BJ
"Microchip-based dialysis of protein samples using photopatterned nanoporous membranes," in MicroTAS 2003, Kluwer Academic Publishers (2003). pdf

Oct 2002
PDF version of Kirby, Shepodd: Microvalve architectures for high-pressure hydraulic and electrokinetic fluid control in microchips

Kirby BJ, Shepodd TJ
"Microvalve Architectures for High-Pressure Hydraulic and Electrokinetic Fluid Control in Microchips," in MicroTAS 2002, Kluwer Academic Publishers, pp. 338-340 (2002). pdf

Oct 2002
PDF version of Kirby, Singh: In-situ fabrication of dialysis membranes in glass microchannels using laser-induced phase-separation polymerization

Kirby BJ, Singh AK
"In-situ Fabrication of Dialysis Membranes in Glass Microchannels Using Laser-induced Phase-separation Polymerization," in MicroTAS 2002, Kluwer Academic Publishers, pp. 742-744 (2002). pdf

Oct 2001
PDF version of Kirby, Wheeler, Shepodd, Fruetel, Hasselbrink, Zare: A laser-polymerized thin film silica surface modification for suppression of cell adhesion and electroosmotic flow in microchannels

Kirby BJ, Wheeler AR, Shepodd TJ, Fruetel JA, Hasselbrink, Jr. EF, Zare RN
"A Laser-Polymerized Thin Film Silica Surface Modification for Suppression of Cell Adhesion and Electroosmotic Flow in Microchannels," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Oct 2001
PDF version of Wheeler, Morishima, Kirby, Leach, Zare: CATH.a neuron cell analysis on a chip with micellar electrokinetic chromatography

Wheeler AR, Morishima K, Kirby BJ, Leach A, Zare RN
"CATH.a Neuron Cell Analysis on a Chip With Micellar Electrokinetic Chromatography," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

A microfluidic injector for mixing and reacting approximately 500 picoliters of fluid at high pressures (70 atm) before injecting the results into a miniaturized high-performance liquid chromatography (HPLC) system. A chemically-etched glass substrate holds laser-polymerized fluoropolymer elements that open and close fluidic channels just like transistors in microelectronic circuits open and close electrical connections.
A microfluidic device incorporating laser-polymerized membranes with biosensing.