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Lab-on-a-Chip and BioMEMS Devices
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Lab-on-a-chip devices (also known as
micro-total-analytical systems or microTAS) are
devices designed to miniaturize analytical or
bioanalytical techniques and integrate them
into a microfabricated format. Techniques such as chemical separations
(electrophoresis, chromatography, etc) or immunoassays are incorporated into
microfabricated systems (typically glass, silicon or polymers) with a goal of increasing
performance, minimizing reagent requirements, and decreasing cost.
BioMEMS devices are similar,
typically focusing on MEMS (microelectromechanical systems)
with biological applications.
We use lab-on-a-chip devices to sort or
study cells, study interfacial phenomena, and produce pharmaceuticals.
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Selected Publications and Presentations on Lab-on-a-Chip and BioMEMS devices
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Hawkins BG,
Gleghorn JP,
Kirby BJ
"Dielectrophoresis for cell and particle manipulation,"
submitted, 2008.
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Kondapalli S,
Kirby BJ
"Refolding of beta-galactosidase: Microfluidic device for reagent metering
and mixing and quantification of refolding yield,"
submitted, 2008.
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George PA, Hui W, Rana F,
Hawkins BG,
Smith AE,
Kirby BJ
"Integrated microfluidic devices for terahertz spectroscopy of biomolecules",
Optics Express, 16(3) 1577-1582 (2008).
pdf
text
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Kondapalli S,
Putnam DA,
Kirby BJ
"Protein refolding in microchips",
AIChE 2007, Salt Lake City, UT, November 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic
screening of Mycobacterium smegmatis in
coherently patterned, polymeric microchannels",
MicroTAS 2007, Paris, France, October 2007.
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Tandon V,
Bhagavatula SK,
Nelson WC,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge",
Electrophoresis 29(5):1092-1101, 2008.
doi
pdf
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Tandon V,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure",
Electrophoresis 29(5):1102-1114, 2008.
doi
pdf
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Hawkins BG,
Smith AE,
Syed YA,
Kirby BJ
"Continuous-flow particle separation by 3D insulative
dielectrophoresis using coherently shaped, DC-biased,
AC electric fields,"
Analytical Chemistry, 2007.
doi
pdf
text
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow particle sorting at low applied electric fields
using electrodeless dielectrophoresis in ridged polymeric devices,"
MicroTAS 2006 Tokyo, Japan, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields,"
2nd New York Complex Matter Workshop Ithaca, NY, June 2006.
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Mela P, van den Berg A, Fintschenko Y,
Cummings EB, Simmons BA,
Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless)
dielectrophoresis particle trapping devices,"
Electrophoresis 26:1792-1799 (2005).
doi
pdf
text
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"Microchip HPLC of peptides and proteins,"
Analytical Chemistry 77:2997-3000 (2005).
doi
pdf
text
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Kirby BJ,
Reichmuth DS, Renzi RF, Shepodd TJ,
Wiedenman BJ "Microfluidic routing of aqueous and
organic flows at high pressure: Fabrication and
characterization of integrated polymer microvalve elements,"
Lab on a Chip 5:184-190 (2005).
doi
pdf
text
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"On-chip
high-pressure picoliter injector for pressure-driven flow
through porous media," Analytical Chemistry
76:5063-5068 (2004).
doi
pdf
text
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Song S, Singh AK,
Kirby BJ
"Electrophoretic
Concentration of Proteins at Laser-Patterned Porous
Membranes," Analytical Chemistry 76:4589-4592 (2004).
doi
pdf
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Song S, Singh AK, Shepodd TJ,
Kirby BJ
"Microchip dialysis of proteins using in situ
photopatterned nanoporous polymer membranes", Analytical
Chemistry 76:2367-2373 (2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 1. Theory, experimental
techniques, and effects on separations,"
Electrophoresis, 25:187-202
(2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 2. Data for polymers,"
Electrophoresis, 25:203-213 (2004).
doi
pdf
text
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Song S, Shepodd TJ, Singh AK,
Kirby BJ
"Microchip-based dialysis of protein
samples using photopatterned nanoporous membranes," in MicroTAS 2003, Kluwer Academic Publishers (2003).
pdf
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"RP-HPLC microchip
separations with subnanoliter on-chip pressure injections," in MicroTAS 2003, Kluwer Academic Publishers (2003).
pdf
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Fintschenko Y,
Kirby BJ,
Hasselbrink, Jr. EF,
Singh AK, Shepodd TJ "Monolithic Materials: Miniature
and Microchip Technologies," in Monolithic Materials:
Preparation, Properties, and Applications Elsevier,
Amsterdam (2003).
pdf
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Kirby BJ,
Wheeler AR, Zare RN, Fruetel JA,
Shepodd TJ "Programmable Modification of Cell Adhesion
and Zeta Potential in Silica Microchips,"Lab On a Chip
3:5-10 (2003).
doi
pdf
text
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Kirby BJ,
Shepodd TJ, Hasselbrink, Jr. EF
"Voltage-Addressable On/Off Microvalves for High-Pressure
Microchip Separations," Journal of Chromatography A
979:147-154 (2002).
doi
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Kirby BJ,
Shepodd TJ "Microvalve
Architectures for High-Pressure Hydraulic and Electrokinetic
Fluid Control in Microchips," in MicroTAS 2002, Kluwer
Academic Publishers, pp. 338-340 (2002).
pdf
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Kirby BJ,
Singh AK "In-situ Fabrication of
Dialysis Membranes in Glass Microchannels Using Laser-induced
Phase-separation Polymerization," in MicroTAS 2002,
Kluwer Academic Publishers, pp. 742-744 (2002).
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