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Nanofluidic Transport
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Nanofluidic phenomena are characterized by length scales ranging roughly
between 1 nm and 100 nm. At these length scales, a number of novel
questions arise, which include the following:
- how exactly does the no-slip condition apply to fluid flow?
- how are fluid constitutive properties (viscosity, dielectric constant)
affected by the presence of the wall?
- how is ion transport affected inside electrical double layers?
- how can the enormous electrical fields inside electrical double
layers be used to advantage?
- how can small channels be used to better manipulate and control macromolecules, such as proteins and
DNA?
Study of nanofluidic phenomena can occur indirectly via interface studies, nanoporous
material, or nanometer-scale microdevices. Click
here
for a recent Analytical Chemistry article on nanofluidics.
We are currently exploring the use of nanoscale structures for
DEP manipulation of nanoparticles and macromolecules,
investigating interfacial phenomena
within nanometers of surfaces, and exploring transport properties in nanoporous material
used for
sample dialysis
or
tissue engineering.
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Publications and Presentations on Nanofluidic Transport
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Kirby BJ
"Micro- and Nanoscale Fluid Mechanics for Engineers,"
textbook in preparation for publication in 2009.
click here for html version|
Cambridge University Press
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Kondapalli SK,
Connelly JT,
Baeumner AJ,
Kirby BJ
"On-chip electrophoretic concentration of liposomes
for antibody-based viral biosensors", ",
MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.
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Kirby BJ
"Nanofluidics" (book review),
Materials Today, 12(5) 51, 2009.
doi
pdf
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Tandon V,
Bhagavatula SK,
Nelson WC,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge",
Electrophoresis 29(5):1092-1101, 2008.
doi
pdf
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Tandon V,
Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure",
Electrophoresis 29(5):1102-1114, 2008.
doi
pdf
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Tandon V,
Bhagavatula SK,
Nelson WC, Sharma AN,
Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH, 2007.
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Reissman TR, Fang A, Garcia ER,
Kirby BJ,
Viard R, Fauchet P
"Inorganic proton exchange membranes," FuelCell 2006, Irvine, CA.
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Mela P, van den Berg A, Fintschenko Y,
Cummings EB, Simmons BA,
Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless)
dielectrophoresis particle trapping devices,"
Electrophoresis 26:1792-1799 (2005).
doi
pdf
text
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"Microchip HPLC of peptides and proteins,"
Analytical Chemistry 77:2997-3000 (2005).
doi
pdf
text
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Kirby BJ,
Reichmuth DS, Renzi RF, Shepodd TJ,
Wiedenman BJ "Microfluidic routing of aqueous and
organic flows at high pressure: Fabrication and
characterization of integrated polymer microvalve elements,"
Lab on a Chip 5:184-190 (2005).
doi
pdf
text
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Reichmuth DS, Chirica GS,
Kirby BJ
"Analysis of peptides using an integrated
microchip HPLC-MS/MS system," in MicroTAS 2004, Kluwer Academic Publishers (2004).
pdf
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Song S, Mela P, van den Berg A,
Kirby BJ
"Microfluidic architectures for integrated cell lysis,
lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004).
pdf
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"On-chip
high-pressure picoliter injector for pressure-driven flow
through porous media," Analytical Chemistry
76:5063-5068 (2004).
doi
pdf
text
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Song S, Singh AK,
Kirby BJ
"Electrophoretic
Concentration of Proteins at Laser-Patterned Porous
Membranes," Analytical Chemistry 76:4589-4592 (2004).
doi
pdf
text |
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Song S, Singh AK, Shepodd TJ,
Kirby BJ
"Fabrication and characterization of photopatterned polymer
membranes for protein concentration and dialysis in microchips," in Hilton Head MEMS Workshop 2004 (2004).
pdf
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Song S, Singh AK, Shepodd TJ,
Kirby BJ
"Microchip dialysis of proteins using in situ
photopatterned nanoporous polymer membranes", Analytical
Chemistry 76:2367-2373 (2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 1. Theory, experimental
techniques, and effects on separations,"
Electrophoresis, 25:187-202
(2004).
doi
pdf
text
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Kirby BJ,
Hasselbrink, Jr. EF "The Zeta
Potential of Microfluidic Substrates. 2. Data for polymers,"
Electrophoresis, 25:203-213 (2004).
doi
pdf
text
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Song S, Shepodd TJ, Singh AK,
Kirby BJ
"Microchip-based dialysis of protein
samples using photopatterned nanoporous membranes," in MicroTAS 2003, Kluwer Academic Publishers (2003).
pdf
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Reichmuth DS, Shepodd TJ,
Kirby BJ
"RP-HPLC microchip
separations with subnanoliter on-chip pressure injections," in MicroTAS 2003, Kluwer Academic Publishers (2003).
pdf
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Reichmuth DS,
Kirby BJ
"Effects of
Ammonioalkyl sulfonate internal salts on electrokinetic
micropump performance and Reversed-Phase HPLC separations,"
Journal of Chromatography A, 1013:93-101
(2003).
doi
pdf
text
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Reichmuth DS, Chirica GS,
Kirby BJ
"Increasing the Performance of High-Pressure,
High-Efficiency Electrokinetic Micropumps Using Zwitterionic
Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003).
doi
pdf
text
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Kirby BJ,
Shepodd TJ, Hasselbrink, Jr. EF
"Voltage-Addressable On/Off Microvalves for High-Pressure
Microchip Separations," Journal of Chromatography A
979:147-154 (2002).
doi
pdf
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Kirby BJ,
Shepodd TJ "Microvalve
Architectures for High-Pressure Hydraulic and Electrokinetic
Fluid Control in Microchips," in MicroTAS 2002, Kluwer
Academic Publishers, pp. 338-340 (2002).
pdf
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Kirby BJ,
Singh AK "In-situ Fabrication of
Dialysis Membranes in Glass Microchannels Using Laser-induced
Phase-separation Polymerization," in MicroTAS 2002,
Kluwer Academic Publishers, pp. 742-744 (2002).
pdf
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News
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Wednesday, November 18, 2009 Kirby to speak at Berkeley Nanosci. and Nanoeng. Institute 4 Dec 2009
Professor Kirby will speak on 4 Dec 2009 at UC-Berkeley, hosted by the Berkeley Nanoscience and Nanoengineering Institute. Click here for …
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Read more...
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Sunday, November 15, 2009 Kirby to speak at Stanford Mechanical Engineering Dept 3 Dec 2009
Prof. Kirby will speak at the Stanford Mechanical Engineering Department on 3 Dec 2009. Click here for seminar schedule.
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