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Nanofluidic Transport
Nanofluidic phenomena are characterized by length scales ranging roughly between 1 nm and 100 nm. At these length scales, a number of novel questions arise, which include the following:
  • how exactly does the no-slip condition apply to fluid flow?
  • how are fluid constitutive properties (viscosity, dielectric constant) affected by the presence of the wall?
  • how is ion transport affected inside electrical double layers?
  • how can the enormous electrical fields inside electrical double layers be used to advantage?
  • how can small channels be used to better manipulate and control macromolecules, such as proteins and DNA?
Study of nanofluidic phenomena can occur indirectly via interface studies, nanoporous material, or nanometer-scale microdevices. Click here for a recent Analytical Chemistry article on nanofluidics. We are currently exploring the use of nanoscale structures for DEP manipulation of nanoparticles and macromolecules, investigating interfacial phenomena within nanometers of surfaces, and exploring transport properties in nanoporous material used for sample dialysis or tissue engineering.

Publications and Presentations on Nanofluidic Transport

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics for Engineers," textbook in preparation for publication in 2009.
click here for html version| Cambridge University Press

Kondapalli SK, Connelly JT, Baeumner AJ, Kirby BJ
"On-chip electrophoretic concentration of liposomes for antibody-based viral biosensors", ", MicroTAS 2009, 1-5 Nov 2009, Jeju, Korea.

PDF version of Brian Kirby Nanofluidics review

Kirby BJ
"Nanofluidics" (book review), Materials Today, 12(5) 51, 2009. doi pdf

PDF version of Tandon V Bhagavatula SK Nelson WC Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices
fabricated from hydrophobic polymers: 1. The origins of charge

Tandon V, Bhagavatula SK, Nelson WC, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge", Electrophoresis 29(5):1092-1101, 2008. doi pdf

PDF version of Tandon V Kirby BJ:
Zeta potential and electroosmotic mobility in microfluidic devices 
fabricated from hydrophobic polymers: 2. Slip and interfacial water structure

Tandon V, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 2. Slip and interfacial water structure", Electrophoresis 29(5):1102-1114, 2008. doi pdf

Tandon V, Bhagavatula SK, Nelson WC, Sharma AN, Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH, 2007.

Reissman TR, Fang A, Garcia ER, Kirby BJ, Viard R, Fauchet P
"Inorganic proton exchange membranes," FuelCell 2006, Irvine, CA.

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

PDF version of Reichmuth, Shepodd, Kirby: Microchip HPLC of peptides and proteins

Reichmuth DS, Shepodd TJ, Kirby BJ
"Microchip HPLC of peptides and proteins," Analytical Chemistry 77:2997-3000 (2005). doi pdf text

PDF version of Kirby, Reichmuth, Renzi, Shepodd, Wiedenman: Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements

Kirby BJ, Reichmuth DS, Renzi RF, Shepodd TJ, Wiedenman BJ
"Microfluidic routing of aqueous and organic flows at high pressure: Fabrication and characterization of integrated polymer microvalve elements," Lab on a Chip 5:184-190 (2005). doi pdf text

PDF version of Reichmuth, Chirica, Kirby: Analysis of peptides using an integrated microchip HPLC-MS/MS system

Reichmuth DS, Chirica GS, Kirby BJ
"Analysis of peptides using an integrated microchip HPLC-MS/MS system," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

PDF version of Song, Mela, van den Berg, Kirby: Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus

Song S, Mela P, van den Berg A, Kirby BJ
"Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

PDF version of Reichmuth, Shepodd, Kirby: On-chip high-pressure picoliter injector for pressure-driven flow through porous media

Reichmuth DS, Shepodd TJ, Kirby BJ
"On-chip high-pressure picoliter injector for pressure-driven flow through porous media," Analytical Chemistry 76:5063-5068 (2004). doi pdf text

PDF version of Song, Singh, Kirby: Electrophoretic concentration of proteins at laser-patterned porous membranes

Song S, Singh AK, Kirby BJ
"Electrophoretic Concentration of Proteins at Laser-Patterned Porous Membranes," Analytical Chemistry 76:4589-4592 (2004). doi pdf text

PDF version of Song, Singh, Shepodd, Kirby: Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Fabrication and characterization of photopatterned polymer membranes for protein concentration and dialysis in microchips," in Hilton Head MEMS Workshop 2004 (2004). pdf

PDF version of Song, Singh, Shepodd, Kirby: Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes

Song S, Singh AK, Shepodd TJ, Kirby BJ
"Microchip dialysis of proteins using in situ photopatterned nanoporous polymer membranes", Analytical Chemistry 76:2367-2373 (2004). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 1. Theory, experimental techniques, and effects on separations

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 1. Theory, experimental techniques, and effects on separations," Electrophoresis, 25:187-202 (2004). doi pdf text

PDF version of Kirby, Hasselbrink: The zeta potential of microfluidic substrates. 2. Data for polymers

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 2. Data for polymers," Electrophoresis, 25:203-213 (2004). doi pdf text

PDF version of Song, Shepodd, Singh, Kirby: Microchip-based dialysis of protein samples using photopatterned nanoporous membranes

Song S, Shepodd TJ, Singh AK, Kirby BJ
"Microchip-based dialysis of protein samples using photopatterned nanoporous membranes," in MicroTAS 2003, Kluwer Academic Publishers (2003). pdf

PDF version of Reichmuth, Shepodd, Kirby: RP-HPLC microchip separations with subnanoliter on-chip pressure injections

Reichmuth DS, Shepodd TJ, Kirby BJ
"RP-HPLC microchip separations with subnanoliter on-chip pressure injections," in MicroTAS 2003, Kluwer Academic Publishers (2003). pdf

PDF version of Reichmuth, Kirby: Effects of ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and reversed-phase HPLC separations

Reichmuth DS, Kirby BJ
"Effects of Ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and Reversed-Phase HPLC separations," Journal of Chromatography A, 1013:93-101 (2003). doi pdf text

PDF version of Reichmuth, Chirica, Kirby: Increasing the performance of high-pressure, high-efficiency electrokinetic micropumps using zwitterionic solute additives

Reichmuth DS, Chirica GS, Kirby BJ
"Increasing the Performance of High-Pressure, High-Efficiency Electrokinetic Micropumps Using Zwitterionic Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003). doi pdf text

PDF version of Kirby, Shepodd, Hasselbrink: Voltage-addressable on/off microvalves for high-pressure microchip separations

Kirby BJ, Shepodd TJ, Hasselbrink, Jr. EF
"Voltage-Addressable On/Off Microvalves for High-Pressure Microchip Separations," Journal of Chromatography A 979:147-154 (2002). doi pdf

PDF version of Kirby, Shepodd: Microvalve architectures for high-pressure hydraulic and electrokinetic fluid control in microchips

Kirby BJ, Shepodd TJ
"Microvalve Architectures for High-Pressure Hydraulic and Electrokinetic Fluid Control in Microchips," in MicroTAS 2002, Kluwer Academic Publishers, pp. 338-340 (2002). pdf

PDF version of Kirby, Singh: In-situ fabrication of dialysis membranes in glass microchannels using laser-induced phase-separation polymerization

Kirby BJ, Singh AK
"In-situ Fabrication of Dialysis Membranes in Glass Microchannels Using Laser-induced Phase-separation Polymerization," in MicroTAS 2002, Kluwer Academic Publishers, pp. 742-744 (2002). pdf

News

Wednesday, November 18, 2009
Kirby to speak at Berkeley Nanosci. and Nanoeng. Institute 4 Dec 2009

Professor Kirby will speak on 4 Dec 2009 at UC-Berkeley, hosted by the Berkeley Nanoscience and Nanoengineering Institute.  Click here for …
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Sunday, November 15, 2009
Kirby to speak at Stanford Mechanical Engineering Dept 3 Dec 2009

Prof. Kirby will speak at the Stanford Mechanical Engineering Department on 3 Dec 2009.  Click here for seminar schedule.