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Microparticle Processing
Because microfluidic devices provide a well-defined geometry that can straightforwardly be massively-parallelized, there exists a great potential for processing particles in microsystems. Applications include:
  • preprocessing complex samples to eliminate particles before injection into a microfluidic device
  • sorting particles so as to improve identification of pathogen spores
  • controlled fabrication of nanoparticles

Archival Publications

HTML version of Kirby: Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices," Cambridge University Press, 2010.
click here for html version| Cambridge University Press

PDF version of Bono, Ahner, Kirby:
Detection of algal lipid accumulation due to nitrogen limitation via dielectric spectroscopy of Chlamydomonas reinhardtii suspensions in a coaxial transmission line sample cell

Bono MS, Ahner BA, Kirby BJ,
"Detection of algal lipid accumulation due to nitrogen limitation via dielectric spectroscopy of Chlamydomonas reinhardtii suspensions in a coaxial transmission line sample cell", Bioresource Technology, Volume 143, pp.623–631, 2013. doi pdf(with errata)

PDF version of Gleghorn, Smith, Kirby
Transport and collision dynamics in periodic asymmetric obstacle arrays:
rational design of micro
fluidic rare cell immunocapture devices

Gleghorn JP, Smith JP, Kirby BJ
"Transport and collision dynamics in periodic asymmetric obstacle arrays: rational design of micro fluidic rare cell immunocapture devices", Physical Review E, 88, 032136 (2013). doi pdf

Hawkins, Huang, Arasanipalai, Kirby: Automated dielectrophoretic chracterization of Mycobacterium smegmatis

Hawkins BG, Huang C, Arasanipalai S, Kirby BJ
"Automated dielectrophoretic chracterization of Mycobacterium smegmatis," Analytical Chemistry, 83 (9), pp 3507–3515, 2011. doi pdf

PDF version of Hawkins, Kirby: Electrothermal flow effects in insulating 
(electrodeless) dielectrophoresis systems

Hawkins BG, Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems," Electrophoresis, 31:3622-3633, 2010. doi pdf

PDF version of Gleghorn, Pratt, Denning, Liu, Bander, Tagawa, Nanus, Giannakakou, Kirby:
Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture (GEDI) and a prostate-specific antibody

Gleghorn JP, Pratt ED, Denning D, Liu H, Bander NH, Tagawa S, Nanus DM, Giannakakou PA, Kirby BJ
"Capture of circulating tumor cells from whole blood of prostate cancer patients using geometrically enhanced differential immunocapture and a prostate-specific antibody", Lab on a Chip, 10:27-29, 2010. doi PubMedCentral pdf

PDF version of AUTHORS: TITLE

Hawkins BG, Gleghorn JP, Kirby BJ
"Dielectrophoresis for cell and particle manipulations," in Methods in Bioengineering: Biomicrofabrication and Biomicrofluidics, Ed. J.D. Zahn, Artech Press, 2009. pdf

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

PDF version of Kirby, Wheeler, Zare, Fruetel, Shepodd: Programmable modification of cell adhesion and zeta potential in silica microchips

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text

Presentations and Other Publications
28 Mar 2013

Bono MS , Ahner BA , Kirby BJ
Quantitative in situ measurement of algal lipid content via dielectric spectroscopy, Division of Analytical Chemistry oral session on "Characterization of Algal Lipids" at the 245th ACS National Meeting, New Orleans, Louisiania.

7 Nov 2012

Kirby BJ
"Electrokinetic and immunospecific characterization of cells for human health and energy applications", SUNY-Buffalo Chemical and Biomolecular Engineering Seminar Series, Buffalo, NY.

24-27 Oct 2012

Kirby BJ
"Dielectric Spectrometry of Mycobacterium and GEDI Devices for Circulating Tumor Cells: Cell Capture, Characterization, and Manipulation in Geometrically Patterned Microstructures", BMES 2012, Atlanta, Georgia.

30 Sep-5 Oct 2012

Kirby BJ
"Dielectric and dielectrophoretic measurements and manipulations of cells for human health and energy applications", SciX 2012, Kansas City, MO.

10-13 May 2012

Kirby BJ
"Geometric patterning: controlling small-scale flows with repeated microstructures", German--American Frontiers of Science Symposium, Potsdam, Germany. | video

28 Mar 2012

Bono MS , Rhoads K , Ahner BA , Kirby BJ
Dielectric measurement of algal lipid content, Division of Analytical Chemistry oral session on "Challenges in Algal Biofuels: Biochemistry, Lipid Extraction and Analysis" at the 243rd ACS National Meeting, San Diego, California.

6-9 Oct 2011

Huang C , Hawkins BG , Arasanipalai S , Kirby BJ
Dielectrophoretic characterization of Mycobacteria and Prostate Cancer Cells, BMES 2011 Annual Meeting, Hartford, CT.

15 sept 2011

Arasanipalai S , Hawkins BG , Huang C , Kirby BJ
Dielectrophoretic separation of Mycobacteria to aid in Tuberculosis research, CNF 2011 Annual Meeting, Ithaca, NY.

10 Jun 2011

Arasanipalai S , Huang C , Hawkins BG , Kirby BJ
Dielectrophoretic separation of Mycobacteria to aid in tuberculosis research, 11th New York Complex Matter Workshop, Syracuse, NY.

10 Jun 2011

Bono MS , Rhoads K , Ahner BA , Kirby BJ
Dielectric measurement of algal lipid content for biodiesel production, 11th New York Complex Matter Workshop, Syracuse, NY.

19-20 Apr 2011

Kirby BJ
NSF National Nanotechnology Infrastructure Network Computation Symposium, Ann Arbor, MI.

30 Mar 2011

Bono MS , Kirby BJ
Microfluidic dielectric spectroscopy of particle and cell solutions, Division of Analytical Chemistry poster session at the 241st ACS National Meeting, Anaheim, California.

7-11 Feb 2011

Kirby BJ
Lorentz workshop on circulating tumor cells, Leiden, The Netherlands.

12-18 Nov 2010

Smith JP , Gleghorn JP , Kirby BJ
"Particle collision dynamics of microparticles in microfluidic obstacle arrays", ASME 2010 International Mechanical Engineering Congress and Exposition, Vancouver, BC.

7-12 Nov 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", AIChE 2010, Salt Lake City, UT.

7-12 Nov 2010

Gleghorn JP , Smith JP , Kirby BJ
"Particle collision dynamics of microparticles in microfluidic obstacle arrays", AIChE 2010, Salt Lake City, UT.

6-9 Oct 2010

Gleghorn JP , Santana SM , Pratt ED , Loftus MS , Jodari-Karimi M , Bander NH , Nanus DM , Giannakakou PA , Kirby BJ
"Cancer cell assays by use of immunocapture, subcellular imaging, and cell release in GEDI microdevices", BMES 2010, Austin, TX.

6-9 Oct 2010

Huang C , Hawkins BG , Arisanipalai S , Kirby BJ
"Automated dielectrophoretic characterization for microfluidic cell separation devices", BMES 2010, Austin, TX.

3-7 Oct 2010

Hawkins BG , Kirby BJ
"Electrothermal flow effects in insulating (electrodeless) dielectrophoresis systems", MicroTAS 2010, Groningen, The Netherlands.

3-7 Oct 2010

Huang C , Hawkins BG , Arisanipalai S , Kirby BJ
"Automated dielectrophoretic characterization for microfluidic cell separation devices", MicroTAS 2010, Groningen, The Netherlands.

18 June 2010

Huang C, Hawkins BG, Kirby BJ
"Automated Dielectrophoretic Characterization for Microfluidic Cell Separation", 10th New York Complex Matter Workshop, Ithaca, NY.

1-5 Nov 2009

Hawkins BG , Huang C, Stranic IS, Kondapalli SKirby BJ
"Particle screening in polymeric microfluidic devices using insulating dielectrophoresis and frequency modulated electric fields", MicroTAS 2009, Jeju, Korea.

1-5 Nov 2009

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"On-chip electrophoretic concentration of liposomes for antibody-based viral biosensors", MicroTAS 2009, Jeju, Korea.

1-5 Nov 2009 Gleghorn JP, Pratt ED, Loftus MS, Levy BE, Bander NH, Nanus DM, Giannakakou PA, Kirby BJ
"High efficiency capture of circulating tumor cells from patient blood using geometrically-enhanced differential immunocapture", MicroTAS 2009, Jeju, Korea.
7-10 Oct 2009

Hawkins BG , Huang C, Kirby BJ
"Dielectrophoretic Characterization and Sorting of Mycobacteria", BMES 2009, Pittsburgh, PA.

27 Jun-3 Jul 2009

Hawkins BG, Kirby BJ
Gordon Research Conference on Microfluidics, Lucca, Italy.

30 Jan 2009

Kirby BJ
"Geometric micro- and mesopatterning for control of cell transport and microenvironemnt in microdevices and tissue-engineered scaffolds", Carnegie-Mellon Mechanical Engineering Seminar Series, Pittsburgh, PA.

27 Oct 2008

Kirby BJ
"Geometric patterning to control cell growth, capture, and transport", NBTC Annual Symposium, Ithaca, NY.

12-16 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic range particle separation via insulating dielectrophoresis", 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS), San Diego, CA.

2-4 Oct 2008

Hawkins BG, Kirby BJ
"High-Dynamic Range Dielelectrophoresis Devices for Cell Screening," Biomedical Engineering Society Annual Fall Meeting, St. Louis, MO.

9-13 July 2008 Hawkins BG, Gleghorn JP, Kondapalli S, Kirby BJ
"Sorting, capture, and concentration of cells in microdevices: geometric design", Joint meeting of the International Society of Biorheology (ISB) and the International Society for Clinical Hemorheology (ISCH), University Park, PA.
10 apr 2008

Kirby BJ
"Electrokinetic Tool of Cellular Screening in Plastic Microdevices: Interfacial Characterization and Engineering Design", Temple University Chemistry Department, Philadelphia, PA.

21 Mar 2008

Kirby BJ
"Cell processing in microdevices: sorting, capturing, and concentration techniques", University of Rochester Biomedical Engineering Department, Rochester, NY.

4 Mar 2008

Kirby BJ
"Micropatterning in injection-molded microdevices and engineered tissue scaffolds: the role of electrokinetic coupling", University of Illinois Mechancal Science and Engineering Department, Urbana, IL

4-9 Nov 2007

Hawkins BG, Smith AE, Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic screening of Mycobacterium smegmatis in coherently patterned, polymeric microchannels", AIChE 2007, Salt Lake City, UT, November 2007.

7-12 Oct 2007.

Hawkins BG, Tandon V, Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial characterization and engineering design", Meeting of the Electrochemical Society, Washington, DC.

7-11 Oct 2007

Hawkins BG, Smith AE, Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic screening of Mycobacterium smegmatis in coherently patterned, polymeric microchannels", MicroTAS 2007, Paris, France, October 2007.

1 Oct 2007 Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype," Nanobiotechnology Symposium, Cornell University, Ithaca, NY.
26-29 Sep 2007

Hawkins BG, Smith AE, Kirby BJ
"Towards Cellular Screening for Mycobacteria: Microchip monitoring of electrical phenotype,"  BMES 2007, Los Angeles, CA.

15-20 Jul 2007

Hawkins BG, Smith AE, Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH.

10 May 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", University of Toronto Analytical Chemistry Seminar Series, Toronto, Canada.

24 Apr 2007

Kirby BJ
"Electromechanical coupling in microfabricated and tissue-engineered systems", Lafayette Bioengineering and Biomedicine Symposium, Easton, PA.

26 Feb 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Biological and Environmental Engineering Seminar Series, Cornell University, Ithaca, NY.

25 Jan 2007

Kirby BJ
"Design and control of micro/nanoscale fluid systems via polymer synthesis and geometric patterning", Textiles and Apparel Seminar Series, Cornell University, Ithaca, NY.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," ASME Congress 2006 Chicago, IL.

Nov 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan.

6 Oct 2006

Kirby BJ
"Fabrication for design and control of micro/nanofluidic systems", University of Michigan Mechanical Engineering Seminar Series, Ann Arbor, MI.

20 Sep 2006

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," CNF annual meeting, Ithaca, NY

Nov 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems," AIChE 2006 San Francisco, CA.

21 Jun 2006

Kirby BJ
"Electrokinetics in fluid systems: Control of fields with multiscale geometric patterning", 2nd New York Complex Matter Workshop, Ithaca, NY.

Dec 2006

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow dielectrophoretic particle separation in polymeric microchannels," 3rd New York Complex Matter Workshop Syracuse, NY.

12 Jan 2006

Kirby BJ
"Miniaturized devices for combinatorial chemistry and nanofluidic study", Sandia National Laboratories, Livermore, CA.

9 Dec 2005

Kirby BJ
Kodak Research Laboratories, Rochester, NY.

10 Nov 2005

Kirby BJ
Mechanical Engineering and Applied Mechanics Department, University of Pennsylvania, Philadelphia, PA.

27 Oct 2005

Kirby BJ
Dept. of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark.

18 Oct 2005

Kirby BJ
Nanobiotechnology Center, Cornell University, Ithaca, NY.

27 Sep 2005

Kirby BJ
Cornell Fluid Dynamics Seminar, Ithaca, NY.

25 July 2005

Kirby BJ
Gordon Research Conference on the Physics and Chemistry of Microfluidics, Oxford, UK.

Jun 2005

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields," 2nd New York Complex Matter Workshop Ithaca, NY.

10 Feb 2005

Kirby BJ
APS March Annual Meeting, San Francisco, CA.

10 Feb 2005

Kirby BJ
Johns Hopkins Mechanical Engineering Seminar Series, Baltimore, MD.

Oct 2004
PDF version of Song, Mela, van den Berg, Kirby: Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus

Song S, Mela P, van den Berg A, Kirby BJ
"Microfluidic architectures for integrated cell lysis, lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004). pdf

Oct 2001
PDF version of Kirby, Wheeler, Shepodd, Fruetel, Hasselbrink, Zare: A laser-polymerized thin film silica surface modification for suppression of cell adhesion and electroosmotic flow in microchannels

Kirby BJ, Wheeler AR, Shepodd TJ, Fruetel JA, Hasselbrink, Jr. EF, Zare RN
"A Laser-Polymerized Thin Film Silica Surface Modification for Suppression of Cell Adhesion and Electroosmotic Flow in Microchannels," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Oct 2001
PDF version of Wheeler, Morishima, Kirby, Leach, Zare: CATH.a neuron cell analysis on a chip with micellar electrokinetic chromatography

Wheeler AR, Morishima K, Kirby BJ, Leach A, Zare RN
"CATH.a Neuron Cell Analysis on a Chip With Micellar Electrokinetic Chromatography," MicroTAS 2001, Kluwer Academic Publishers, (2001). pdf

Microfluidics - Brian Kirby, Cornell University from Kavli Frontiers of Science on Vimeo.

Professor Kirby's talk at the German--American Frontiers of Science conference, 2012.
Prof. Kirby's radio interview with Morning News Watch on WHCU, Summer 2012.