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Microparticle Processing
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Because microfluidic devices provide a well-defined geometry that can
straightforwardly be massively-parallelized, there exists a great potential
for processing particles in microsystems. Applications include:
- preprocessing complex samples to eliminate particles before injection into a
microfluidic device
- sorting particles so as to improve identification of pathogen spores
- controlled fabrication of nanoparticles
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Publications and Presentations on Microparticle Processing
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Hawkins BG,
Gleghorn JP,
Kirby BJ
"Dielectrophoresis for cell and particle manipulation,"
submitted, 2008.
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Hawkins BG,
Smith AE,
Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic
screening of Mycobacterium smegmatis in
coherently patterned, polymeric microchannels",
AIChE 2007, Salt Lake City, UT, November 2007.
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Hawkins BG,
Tandon V,
Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial
characterization and engineering design",
Meeting of the Electrochemical Society, Washington, DC, October 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
"High-throughput, continuous-flow, dielectrophoretic
screening of Mycobacterium smegmatis in
coherently patterned, polymeric microchannels",
MicroTAS 2007, Paris, France, October 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
"Towards cellular screening for Mycobacteria: Microchip
monitoring of electrical phenotype",
BMES 2007, Los Angeles, CA, September 2007.
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Hawkins BG,
Smith AE,
Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH, 2007.
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Hawkins BG,
Smith AE,
Syed YA,
Kirby BJ
"Continuous-flow particle separation by 3D insulative
dielectrophoresis using coherently shaped, DC-biased,
AC electric fields,"
Analytical Chemistry, 2007.
doi
pdf
text
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Hawkins BG,
Smith AE, Syed YA,
Kirby BJ
"Continuous-flow dielectrophoretic particle separation in polymeric
microchannels,"
3rd New York Complex Matter Workshop Syracuse, NY, Dec 2006.
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Hawkins BG,
Smith AE, Syed YA,
Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems,"
AIChE 2006 San Francisco, CA, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow particle sorting at low applied electric fields
using electrodeless dielectrophoresis in ridged polymeric devices,"
MicroTAS 2006 Tokyo, Japan, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow particle sorting at low applied electric fields
using electrodeless dielectrophoresis in ridged polymeric devices,"
ASME Congress 2006 Chicago, IL, Nov 2006.
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Smith AE,
Hawkins BG,
Syed YA,
Kirby BJ
"Continuous-flow dielectrophoresis using geometric control of electric fields,"
2nd New York Complex Matter Workshop Ithaca, NY, June 2006.
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Mela P, van den Berg A, Fintschenko Y,
Cummings EB, Simmons BA,
Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless)
dielectrophoresis particle trapping devices,"
Electrophoresis 26:1792-1799 (2005).
doi
pdf
text
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Song S, Mela P, van den Berg A,
Kirby BJ
"Microfluidic architectures for integrated cell lysis,
lysate dialysis and cell stimulus," in MicroTAS 2004, Kluwer Academic Publishers (2004).
pdf
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Kirby BJ,
Wheeler AR, Zare RN, Fruetel JA,
Shepodd TJ
"Programmable Modification of Cell Adhesion
and Zeta Potential in Silica Microchips,"Lab On a Chip
3:5-10 (2003).
doi
pdf
text
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Kirby BJ,
Wheeler AR, Shepodd TJ, Fruetel JA,
Hasselbrink, Jr. EF, Zare RN
"A Laser-Polymerized Thin
Film Silica Surface Modification for Suppression of Cell
Adhesion and Electroosmotic Flow in Microchannels,"
MicroTAS 2001, Kluwer Academic Publishers,
(2001).
pdf
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Wheeler AR, Morishima K,
Kirby BJ,
Leach A,
Zare RN
"CATH.a Neuron Cell Analysis on a Chip With
Micellar Electrokinetic Chromatography," MicroTAS 2001,
Kluwer Academic Publishers, (2001).
pdf
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Cartoon of cellular transport through a constriction in
the presence of
dielectrophoresis. Place mouse on image to animate.
Here, a high-DEP cell (red) is deflected as compared to a
low-DEP cell (green).
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