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Research Projects in the Micro/Nanofluidics Laboratory

Specific ongoing projects include:

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Some recent projects include:

A microchip used to capture circulating tumor cells from the peripheral blood of castrate-resistant prostate cancer patients.
Growth curves for Chlorella vulgaris (blue) and Chlamydomonas reinhardtii (green), measured via chlorophyll autofluorescence.
A circulating tumor cell captured by a GEDI device (refs here and here) from peripheral blood of a castrate-resistant prostate cancer patient shows response to chemotherapeutics. This cell shows an intact nucleus (blue DAPI stain, upper left), stains negative for CD45 (not shown) and positive for cytokeratin (lower left), and, upon incubation with the tubulin-stabilizing drug paclitaxel (Taxol), Top: immunofluorescent stain of tubulin of a circulating tumor cell incubated with 100 nM docetaxel (Taxotere) shows diffuse tubulin and no evidence of bundling. The absence of taxane response is indicative of a lack of drug-target engagement and is consistent with this patient's failure to response to Taxotere therapy. Bottom: immunofluorescent stain of tubulin of a cirulating tumor cell from the same patient incubated with 100 nM paclitaxel (Taxol) shows pronounced tubulin bundling, indicative of drug-target engagement and consistent with this patient's positive clinical response to Taxol.