|
Rare cell capture from blood is exciting owing to the potential
to derive clinical benefit with minimal inconvenience and discomfort to patients.
Information derived from rare cells (e.g., fetal cells in mothers or cancer cells
in cancer patients) can be used in lieu of information from biopsies and thus
improve patient outcomes.
Microfluidic devices are ideally suited for these processes, owing to the
flexibility of geometric design, wealth of chemical manipulation techniques, and
assay compatibility of current systems.
Our current work, in collaboration with Neil Bander, Evi Giannakakou, and David Nanus
at Weill Cornell Medical Center, is focused on microfluidic capture of circulating
tumor cells from prostate cancer patients with a view towards preclinical evaluation
of chemotherapeutic efficacy.
|