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Continuous-Flow Dielectrophoretic Bioparticle Manipulation
Funding: DOE, NSF
We are developing unique microchannel geometries that enable efficient and rationally designed continuous-flow dielectrophoretic manipulation of bioparticles as part of integrated biotoxin analysis systems.

On this project, we are working in close collaboration with Sandia National Laboratories to develop, design, fabricate, and test a unique family of microchannel geometries and their ability to provide novel particle manipulation capabilities.

Selected Publications and Presentations on Dielectrophoretic Bioparticle Processing

Hawkins BG, Gleghorn JP, Kirby BJ
"Dielectrophoresis for cell and particle manipulation," submitted, 2008.

Hawkins BG, Tandon V, Kirby BJ
"Electrokinetic tools for cellular screening in plastic microdevices: interfacial characterization and engineering design", Meeting of the Electrochemical Society, Washington, DC, October 2007.

Hawkins BG, Smith AE, Kirby BJ
"Towards cellular screening for Mycobacteria: Microchip monitoring of electrical phenotype", BMES 2007, Los Angeles, CA, September 2007.

Hawkins BG, Smith AE, Kirby BJ
Gordon Research Conference on Microfluidics, Waterville Valley, NH, 2007.

PDF version of Benjamin G. Hawkins, A. Ezekial Smith, 
Yusef A. Syed, Brian J. Kirby: 
Continuous-Flow Particle Separation 
by 3D Insulative Dielectrophoresis 
Using Coherently Shaped, dc-Biased, ac Electric Fields

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Continuous-flow particle separation by 3D insulative dielectrophoresis using coherently shaped, DC-biased, AC electric fields," Analytical Chemistry, 2007. doi pdf text

Hawkins BG, Smith AE, Syed YA, Kirby BJ
"Electrokinetic particle sorting in cyclic olefin polymer microsystems," AIChE 2006 San Francisco, CA, Nov 2006.

Smith AE, Hawkins BG, Syed YA, Kirby BJ
"Continuous-flow particle sorting at low applied electric fields using electrodeless dielectrophoresis in ridged polymeric devices," MicroTAS 2006 Tokyo, Japan, Nov 2006.

PDF version of Mela, van den Berg, Fintschenko, Cummings, Simmons, Kirby: The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

SEM of Mycobacterium tuberculosis, the causative agent of TB (image credit: CDC). We are studying the use of dielectrophoretic techniques to screen Mycobacterium cells.
Electrodeless dielectrophoretic trapping of microparticles. (click here for source). We are developing novel techniques for manipulating microparticles and cells, many of which involve dielectrophoretic manipulation.