Kirby Lab Microfluidics / Nanofluidics : Electrokinetic properties of surfaces

Cornell University, College of Engineering

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Dielectrophoretic characterization of algae biodiesel feedstocks

Electrokinetic properties of surfaces

Detection of viral pathogens in environmental waters

Electrokinetics in Tissue-Engineered Cartilage Scaffolds

Dielectrophoretic Particle Manipulation

Microfluidic control of neural development

Microfluidic circulating tumor cell capture

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Microfluidics Gordon Research Conference

Microfluidics Gordon Research Seminar

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Electrokinetic Properties of Microfluidic Substrates

Funding: DOE, Lockheed Martin, Cornell, ACS-PRF

Among the unique properties of microfluidic devices is the ability to move liquids via electroosmosis. When the solid-liquid interface acquires a surface charge, an electrical double layer is formed as ions in the electrolyte solution align preferentially based on their charge. When this occurs, an electric field applied parallel to the wall will induce fluid flow.

Modeling and predicting the electrokinetic properties of microfluidic substrates that lead to electroosmosis is inherently difficult. The surface charges are a function of chemical reactions and adsorption/desorption processes, many of which are not fully understood. Further, the electrical double layer is often nanometers thick, and bulk fluid properties typically do not apply close to the wall, where the highest charge density (and therefore most of the action) resides.

Our work on the electrokinetic properties of microfluidic substrates includes (1) experimental characterization of interface properties, (2) chemical modification of interface properties, and (3) analytical and numerical modeling of double layer phenomena.

Publications and Presentations on Electrokinetic Properties of Microfluidic Substrates

Connelly JT, Kondapalli S, Parker, J Kirby BJ, Baeumner AJ
"Micro total analysis system for virus detection:microfluidic pre-concentration coupled to liposome-based detection," Analytical and Bioanalytical Chemistry, accepted, 2011.

Kondapalli S, Connelly JT, Baeumner AJ, Kirby BJ
"Integrated microfluidic preconcentrator and immunobiosensor," Microfluidics and Nanofluidics, 2011. doi

Tandon VT, Kirby BJ
"Ambient Pressure Effects on the Electrokinetic Potential of Zeonor-Water Interfaces," Journal of Colloid and Interface Science, 361:381-387, 2011. doi

Kirby BJ
"Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices," Cambridge University Press, 2010.
click here for html version| Cambridge University Press

Tandon VT, Bhagavatula S, Kirby BJ
"Transient Zeta Potential Measurements in Hydrophobic, TOPAS Microfluidic Substrates," Electrophoresis 30(15) 2656-2667, 2009. doi pdf

Tandon V, Bhagavatula SK, Nelson WC, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 1. The origins of charge", Electrophoresis 29(5):1092-1101, 2008. doi pdf

Tandon V, Kirby BJ
"Zeta potential and electroosmotic mobility in microfluidic devices fabricated from hydrophobic polymers: 2. Slip and interfacial water structure", Electrophoresis 29(5):1102-1114, 2008. doi pdf

Wilkes JO , with Birmingham SG, Kirby BJ, Cheng C-Y
"Fluid Mechanics for Chemical Engineers with Microfluidics and CFD," Prentice-Hall, 2005.
click here to go to text webpage

Mela P, van den Berg A, Fintschenko Y, Cummings EB, Simmons BA, Kirby BJ
"The zeta potential of cyclo-olefin polymer microchannels and its effects on insulative (electrodeless) dielectrophoresis particle trapping devices," Electrophoresis 26:1792-1799 (2005). doi pdf text

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 1. Theory, experimental techniques, and effects on separations," Electrophoresis, 25:187-202 (2004). doi pdf text

Kirby BJ, Hasselbrink, Jr. EF
"The Zeta Potential of Microfluidic Substrates. 2. Data for polymers," Electrophoresis, 25:203-213 (2004). doi pdf text

Reichmuth DS, Kirby BJ
"Effects of Ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and Reversed-Phase HPLC separations," Journal of Chromatography A, 1013:93-101 (2003). doi pdf text

Reichmuth DS, Chirica GS, Kirby BJ
"Increasing the Performance of High-Pressure, High-Efficiency Electrokinetic Micropumps Using Zwitterionic Solute Additives," Sensors and Actuators B-Chemical, 92:37-43 (2003). doi pdf text

Kirby BJ, Wheeler AR, Zare RN, Fruetel JA, Shepodd TJ
"Programmable Modification of Cell Adhesion and Zeta Potential in Silica Microchips,"Lab On a Chip 3:5-10 (2003). doi pdf text


	The evolution of electrokinetic potential observed at Zeonor-water interfaces as a function of time. The decay is fastest at low ambient pressures. (see ref at the journal website here).